感染 SARS-CoV-2 后的性别偏向性免疫反应。
Sex-biased Immune Responses Following SARS-CoV-2 Infection.
机构信息
Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
出版信息
Trends Microbiol. 2020 Dec;28(12):952-954. doi: 10.1016/j.tim.2020.10.002. Epub 2020 Oct 10.
Abstract
Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucidating the mechanisms that underlie the male bias in severe disease and death from coronavirus disease 2019 (COVID-19).
摘要
男性在严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染导致的严重疾病和死亡中受到不成比例的影响。在他们最近的文章中，高桥等人发现了 SARS-CoV-2 免疫反应中的性别差异以及疾病进展的预测因素。这些发现有助于阐明导致 2019 年冠状病毒病 (COVID-19) 中男性严重疾病和死亡的偏倚的机制。
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