Department of Infectious Diseases and the Key Lab of Endogenous Infection, The Sixth Affiliated Hospital of Shenzhen University Health Science Center, No 89, Taoyuan Road, Nanshan District, 518052, Shenzhen, China.
J Antibiot (Tokyo). 2021 Feb;74(2):143-151. doi: 10.1038/s41429-020-00374-2. Epub 2020 Oct 19.
Solithromycin (SOL), a fourth-generation macrolide and ketolide, has been reported to have robust antibacterial activity against a wide spectrum of Gram-positive bacteria. However, the impact of SOL on planktonic growth and biofilm formation of clinical enterococcus isolates remains unclear. In this study, 276 Enterococcus faecalis isolates and 122 Enterococcus faecium were retrospectively collected from a tertiary hospital from China. SOL against clinical isolates of enterococci from China were evaluated the antimicrobial activity in comparison with erythromycin, and explore its relationship with the clonality, virulence genes and resistance mechanism of these isolates. Our data showed that the MICs of SOL against clinical E. faecalis and E. faecium isolates from China were ≤4 and ≤8 mg l, respectively. ST16 and ST179 were regarded as the risk factor to SOL resistance in E. faecalis. SOL could inhibit but not eradicate the biofilm formation of E. faecalis. The bactericidal effects of SOL against E. faecalis and E. faecium were demonstrated to be similar to linezolid and vancomycin using time-kill assays. In conclusion, SOL showed significantly enhanced antibacterial activity against clinical isolates of E. faecalis and E. faecium from China in comparison to erythromycin. Furthermore, SOL could inhibit the biofilm formation of E. faecalis and have the similar bactericidal ability as linezolid and vancomycin against both E. faecalis and E. faecium.
索利霉素（SOL）是一种第四代大环内酯类和酮内酯类抗生素，具有广谱抗革兰氏阳性菌的活性。然而，SOL 对临床肠球菌分离株浮游生长和生物膜形成的影响尚不清楚。本研究回顾性收集了来自中国一家三甲医院的 276 株粪肠球菌和 122 株屎肠球菌。与红霉素相比，评估了 SOL 对中国肠球菌临床分离株的抗菌活性，并探讨了其与这些分离株的克隆性、毒力基因和耐药机制的关系。我们的数据表明，SOL 对中国粪肠球菌和屎肠球菌临床分离株的 MICs 分别为≤4 和≤8mg/L。ST16 和 ST179 被认为是粪肠球菌对 SOL 耐药的危险因素。SOL 可以抑制但不能消除粪肠球菌的生物膜形成。时间杀伤试验表明，SOL 对粪肠球菌和屎肠球菌的杀菌作用与利奈唑胺和万古霉素相似。总之，与红霉素相比，SOL 对中国临床分离的粪肠球菌和屎肠球菌显示出显著增强的抗菌活性。此外，SOL 可以抑制粪肠球菌的生物膜形成，并且对粪肠球菌和屎肠球菌具有与利奈唑胺和万古霉素相似的杀菌能力。
