Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Covilhã, Portugal.
Laboratório de Fármaco-Toxicologia - UBIMedical, Universidade da Beira Interior, Covilhã, Portugal.
Bioanalysis. 2020 Nov;12(21):1557-1595. doi: 10.4155/bio-2020-0148. Epub 2020 Oct 20.
One of the problems associated with the consumption of new psychoactive substances is that in most scenarios of acute toxicity the possibility of quick clinical action may be impaired because many screening methods are not responsive to them, and laboratories are not able to keep pace with the appearance of new substances. For these reasons, developing and validating new analytical methods is mandatory in order to efficiently face those problems, allowing laboratories to be one step ahead. The goal of this work is to perform a critical review regarding bionalytical methods that can be used for the determination of new psychoactive substances (phenylethylamines, cathinones, synthetic cannabinoids, opioids, benzodiazepines, etc), particularly concerning sample preparation techniques and associated analytical methods.
新精神活性物质的使用会带来一些问题，其中之一是大多数急性中毒的情况下，可能无法快速采取临床措施，因为许多筛选方法对其不起作用，且实验室也无法跟上新物质出现的速度。基于这些原因，开发和验证新的分析方法是非常必要的，这可以帮助实验室有效地应对这些问题，使其能抢占先机。本工作旨在对可用于测定新精神活性物质（苯乙胺类、卡西酮类、合成大麻素类、阿片类、苯二氮䓬类等）的分析方法（特别是样品前处理技术和相关分析方法）进行批判性评估。
