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天然来源的精神活性物质：毒理学方面、治疗特性及生物样本中的分析。

Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples.

机构信息

Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.

Laboratório de Fármaco-Toxicologia, UBIMedical, Universidade da Beira Interior, Estrada Municipal 506, 6200-284 Covilhã, Portugal.

出版信息

Molecules. 2021 Mar 5;26(5):1397. doi: 10.3390/molecules26051397.

DOI:10.3390/molecules26051397
PMID:33807728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7961374/
Abstract

The consumption of new psychoactive substances (NPSs) has been increasing, and this problem affects several countries worldwide. There is a class of NPSs of natural origin, consisting of plants and fungi, which have a wide range of alkaloids, responsible for causing relaxing, stimulating or hallucinogenic effects. The consumption of some of these substances is prompted by religious beliefs and cultural reasons, making the legislation very variable or even ambiguous. However, the abusive consumption of these substances can present an enormous risk to the health of the individuals, since their metabolism and effects are not yet fully known. Additionally, NPSs are widely spread over the internet, and their appearance is very fast, which requires the development of sophisticated analytical methodologies, capable of detecting these compounds. Thus, the objective of this work is to review the toxicological aspects, traditional use/therapeutic potential and the analytical methods developed in biological matrices in twelve plant specimens (, , , , , , , , , , and ).

摘要

新精神活性物质（NPS）的消费不断增加，这个问题影响着全球多个国家。有一类天然来源的 NPS，由植物和真菌组成，它们含有广泛的生物碱，负责引起放松、刺激或致幻作用。一些这些物质的消费是出于宗教信仰和文化原因，使得立法非常多变，甚至模糊不清。然而，这些物质的滥用消费可能会对个人健康造成巨大风险，因为它们的新陈代谢和作用尚未完全了解。此外，NPS 在互联网上广泛传播，它们的出现非常迅速，这需要开发复杂的分析方法，以检测这些化合物。因此，这项工作的目的是综述十二种植物标本（、、、、、、、、、和）的毒理学方面、传统用途/治疗潜力以及在生物基质中开发的分析方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/33cc09273889/molecules-26-01397-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/8fa4fe0d7194/molecules-26-01397-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/2a770719adf2/molecules-26-01397-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/c8f8828de122/molecules-26-01397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/cd74ecba5cbd/molecules-26-01397-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/1f60b9dae59b/molecules-26-01397-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/c7afca18becb/molecules-26-01397-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/669bdab5460b/molecules-26-01397-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/03603cd71519/molecules-26-01397-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/7333fcaacffe/molecules-26-01397-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/33cc09273889/molecules-26-01397-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/8fa4fe0d7194/molecules-26-01397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/c0ea7222c3dc/molecules-26-01397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/c70bfd126c82/molecules-26-01397-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/2a770719adf2/molecules-26-01397-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/c8f8828de122/molecules-26-01397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/cd74ecba5cbd/molecules-26-01397-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/1f60b9dae59b/molecules-26-01397-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/c7afca18becb/molecules-26-01397-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/669bdab5460b/molecules-26-01397-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/03603cd71519/molecules-26-01397-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/7333fcaacffe/molecules-26-01397-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/807c/7961374/33cc09273889/molecules-26-01397-g012.jpg

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