Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, Madrid, 28040, Spain.
Centro de Investigación Biomédica en Red-CIBER, Madrid, 28029, Spain.
Biotechnol J. 2021 Mar;16(3):e1900438. doi: 10.1002/biot.201900438. Epub 2020 Nov 9.
Combination therapy has emerged as one of the most promising approaches for cancer treatment. However, beyond remotely-triggered therapies that require advanced infrastructures and optimization, new combination therapies based on internally triggered cell-killing effects have also demonstrated promising therapeutic profiles. In this revision, the focus is on self-triggered strategies able to improve the therapeutic effect of drug delivery nanosystems. As reviewed, ferroptosis, hypoxia, and immunotherapy show potency enough to treat satisfactorily tumors in vivo. However, the interest of combining those with chemotherapeutics, especially with carriers based on mesoporous silica, has provided a new generation of therapeutic nanomedicines with potential enough to achieve complete tumor remission in murine models.
联合治疗已成为癌症治疗最有前途的方法之一。然而，除了需要先进基础设施和优化的远程触发治疗外，基于内部触发细胞杀伤效应的新联合治疗也显示出有希望的治疗特征。在本次修订中，重点是能够提高药物递送纳米系统治疗效果的自触发策略。正如综述中所讨论的，铁死亡、缺氧和免疫疗法具有足够的效力，可以在体内有效地治疗肿瘤。然而，将这些疗法与化疗药物联合使用的兴趣，特别是与介孔硅为基础的载体联合使用的兴趣，为具有足够潜力在小鼠模型中实现完全肿瘤消退的新一代治疗性纳米药物提供了可能。
