Gándara Zoila, Rubio Noelia, Castillo Rafael R
Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, 28805 Alcalá de Henares, Spain.
Instituto de Investigación Química "Andrés M. del Río" (IQAR), Universidad de Alcalá, 28805 Alcalá de Henares, Spain.
Pharmaceutics. 2023 Jan 20;15(2):351. doi: 10.3390/pharmaceutics15020351.
The use of nanoparticles is crucial for the development of a new generation of nanodevices for clinical applications. Silica-based nanoparticles can be tailored with a wide range of functional biopolymers with unique physicochemical properties thus providing several advantages: (1) limitation of interparticle interaction, (2) preservation of cargo and particle integrity, (3) reduction of immune response, (4) additional therapeutic effects and (5) cell targeting. Therefore, the engineering of advanced functional coatings is of utmost importance to enhance the biocompatibility of existing biomaterials. Herein we will focus on the most recent advances reported on the delivery and therapeutic use of silica-based nanoparticles containing biopolymers (proteins, nucleotides, and polysaccharides) with proven biological effects.
纳米颗粒的使用对于开发用于临床应用的新一代纳米器件至关重要。基于二氧化硅的纳米颗粒可以与具有独特物理化学性质的多种功能性生物聚合物进行定制，从而提供几个优点：（1）限制颗粒间相互作用；（2）保持货物和颗粒完整性；（3）降低免疫反应；（4）额外的治疗效果；（5）细胞靶向。因此，先进功能涂层的工程设计对于提高现有生物材料的生物相容性至关重要。在此，我们将重点关注有关含生物聚合物（蛋白质、核苷酸和多糖）且具有已证实生物学效应的二氧化硅基纳米颗粒的递送和治疗用途的最新进展。
