乳腺癌幸存者的低身体活动水平、疲劳和抑郁：IL-6 和 IL-8 水平的调节作用。
Low physical activity, fatigue and depression in breast cancer survivors: Moderation by levels of IL-6 and IL-8.
机构信息
School of Social Work, University of Haifa, Haifa, Israel.
Oranim Academic College of Education, Kiryat Tivon, Israel.
出版信息
Int J Psychophysiol. 2020 Dec;158:96-102. doi: 10.1016/j.ijpsycho.2020.09.011. Epub 2020 Oct 17.
BACKGROUND AND AIMS
Although previous studies suggested that depressed mood and fatigue among cancer survivors are associated with chronic inflammation, the effect of cytokines on the relation between physical activity and fatigue and depressed mood is characterized by inconsistent results. The aim was to examine levels of pro-inflammatory (IL-6, IL-8, TNFα, IL-12) and anti-inflammatory (IL-10) cytokines in relation to the effects of physical activity on fatigue and depressed mood.
METHODS
Breast cancer survivors (n = 108; stages I-III), aged >20 and who were 1-6 months postchemotherapy were recruited consecutively. Participants completed the Fatigue Symptom Inventory and Center for Epidemiologic Studies Depression Scale and reported physical activity details; 10 cc of blood were drawn for assessment of levels of IL-6, IL-8, IL-10, Il-12, and TNFα in serum.
RESULTS
Only IL-6 and IL-8 were associated with fatigue and depressed mood. Controlling for background variables, physical activity and IL-6 were significantly associated with fatigue, but only physical activity was significantly associated with depressed mood. A moderated effect of IL-6 and IL-8 was found in the association of physical activity and fatigue, indicating that this association is significant only in individuals with lower levels of IL-6 or IL-8.
CONCLUSIONS
Fatigue and depressed mood are differently associated with pro-inflammatory cytokines. In addition, IL-6 and IL-8 are main cytokines affected by physical activity. The study stresses the need to provide information and tailored guidance for cancer survivors for maintaining an active lifestyle into survivorship and the importance of allocating resources for programs to encourage active lifestyles among cancer survivors. Caution should be exercised in the interpretation of the results due to the cross-sectional design and possibility of bidirectional associations between the study variables.
背景和目的
尽管先前的研究表明，癌症幸存者的抑郁情绪和疲劳与慢性炎症有关，但细胞因子对体力活动与疲劳和抑郁情绪之间关系的影响尚存在不一致的结果。本研究旨在检测促炎细胞因子（IL-6、IL-8、TNFα、IL-12）和抗炎细胞因子（IL-10）的水平与体力活动对疲劳和抑郁情绪的影响之间的关系。
方法
连续招募了 108 名年龄>20 岁且化疗后 1-6 个月的乳腺癌幸存者（I-III 期）。参与者完成了疲劳症状量表和流行病学研究抑郁量表，并报告了体力活动细节；抽取 10cc 血液用于评估血清中 IL-6、IL-8、IL-10、Il-12 和 TNFα 的水平。
结果
只有 IL-6 和 IL-8 与疲劳和抑郁情绪有关。控制背景变量后，体力活动与 IL-6 与疲劳显著相关，但只有体力活动与抑郁情绪显著相关。IL-6 和 IL-8 的调节作用在体力活动与疲劳的关系中发现，表明这种关系仅在 IL-6 或 IL-8 水平较低的个体中具有显著性。
结论
疲劳和抑郁情绪与促炎细胞因子的相关性不同。此外，IL-6 和 IL-8 是受体力活动影响的主要细胞因子。该研究强调了为癌症幸存者提供信息和量身定制的指导以保持积极生活方式进入生存阶段的必要性，以及为鼓励癌症幸存者积极生活方式的项目分配资源的重要性。由于研究变量之间存在横断面设计和双向关联的可能性，因此在解释结果时应谨慎。
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