All authors: The Ohio State University, Columbus, OH.
J Clin Oncol. 2014 Apr 1;32(10):1040-9. doi: 10.1200/JCO.2013.51.8860. Epub 2014 Jan 27.
To evaluate yoga's impact on inflammation, mood, and fatigue.
A randomized controlled 3-month trial was conducted with two post-treatment assessments of 200 breast cancer survivors assigned to either 12 weeks of 90-minute twice per week hatha yoga classes or a wait-list control. The main outcome measures were lipopolysaccharide-stimulated production of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β), and scores on the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), the vitality scale from the Medical Outcomes Study 36-item Short Form (SF-36), and the Center for Epidemiological Studies-Depression (CES-D) scale.
Immediately post-treatment, fatigue was not lower (P > .05) but vitality was higher (P = .01) in the yoga group compared with the control group. At 3 months post-treatment, fatigue was lower in the yoga group (P = .002), vitality was higher (P = .01), and IL-6 (P = .027), TNF-α (P = .027), and IL-1β (P = .037) were lower for yoga participants compared with the control group. Groups did not differ on depression at either time (P > .2). Planned secondary analyses showed that the frequency of yoga practice had stronger associations with fatigue at both post-treatment visits (P = .019; P < .001), as well as vitality (P = .016; P = .0045), but not depression (P > .05) than simple group assignment; more frequent practice produced larger changes. At 3 months post-treatment, increasing yoga practice also led to a decrease in IL-6 (P = .01) and IL-1β (P = .03) production but not in TNF-α production (P > .05).
Chronic inflammation may fuel declines in physical function leading to frailty and disability. If yoga dampens or limits both fatigue and inflammation, then regular practice could have substantial health benefits.
评估瑜伽对炎症、情绪和疲劳的影响。
这是一项为期 3 个月的随机对照试验，共纳入 200 名乳腺癌幸存者，将其随机分为两组，分别接受 12 周、每周 2 次、每次 90 分钟的哈他瑜伽课程或候补对照组。主要结局指标为脂多糖刺激产生的促炎细胞因子白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β），以及多维疲劳症状量表-短表（MFSI-SF）、医疗结局研究 36 项简短健康调查量表（SF-36）活力量表和流行病学研究中心抑郁量表（CES-D）的评分。
治疗后即刻，与对照组相比，瑜伽组的疲劳程度没有降低（P>0.05），但活力水平更高（P=0.01）。治疗后 3 个月，瑜伽组的疲劳程度更低（P=0.002），活力水平更高（P=0.01），白细胞介素-6（P=0.027）、肿瘤坏死因子-α（P=0.027）和白细胞介素-1β（P=0.037）水平也更低。两组在任何时候的抑郁程度都没有差异（P>0.2）。计划的次要分析表明，瑜伽练习的频率与治疗后两次访视的疲劳程度（P=0.019；P<0.001）以及活力（P=0.016；P=0.0045）的相关性更强，而与抑郁的相关性较弱（P>0.05），但与单纯的分组分配相比，更频繁的练习会产生更大的变化。治疗后 3 个月，增加瑜伽练习还可导致白细胞介素-6（P=0.01）和白细胞介素-1β（P=0.03）的产生减少，但肿瘤坏死因子-α的产生没有变化（P>0.05）。
慢性炎症可能导致身体功能下降，导致虚弱和残疾。如果瑜伽能减轻或限制疲劳和炎症，那么定期练习可能会带来显著的健康益处。
