Research Service, Department of Veterans Affairs Omaha-Western Iowa Health Care System, Omaha, NE, 68105, United States; Pulmonary, Critical Care and Sleep, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5910, United States.
Pulmonary, Critical Care and Sleep, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198-5910, United States.
Alcohol. 2021 Feb;90:11-17. doi: 10.1016/j.alcohol.2020.10.003. Epub 2020 Oct 18.
Alcohol misuse is long established as a contributor to the pathophysiology of the lung. The intersection of multi-organ responses to alcohol-mediated tissue injury likely contributes to the modulation of lung in response to injury. Indeed, the negative impact of alcohol on susceptibility to infection and on lung barrier function is now well documented. Thus, the alcohol lung represents a very likely comorbidity for the negative consequences of both COVID-19 susceptibility and severity. In this review, we present the known alcohol misuse ramifications on the lung in the context of the current coronavirus pandemic.
酗酒是导致肺部病理生理学改变的一个公认因素。酒精介导的组织损伤导致多器官反应的交叉，可能对肺损伤的反应产生调节作用。事实上，酒精对感染易感性和肺屏障功能的负面影响已得到充分证实。因此，酒精性肺病很可能是 COVID-19 易感性和严重程度的负面影响的一种合并症。在这篇综述中，我们根据当前的冠状病毒大流行，介绍了已知的酒精滥用对肺部的影响。
