Bartolotta Tommaso Vincenzo, Sidoti Pinto Antonio, Cannella Roberto, Porrello Giorgia, Taravella Rossana, Randazzo Angelo, Taibbi Adele
Section of Radiology - BiND, University Hospital "Paolo Giaccone", Palermo, Italy.
Department of Radiology, Fondazione Istituto Giuseppe Giglio, Palermo, Italy.
Ultrasonography. 2021 Jul;40(3):333-341. doi: 10.14366/usg.20025. Epub 2020 Aug 19.
This study was conducted to assess the interobserver and intraobserver agreement of three-dimensional contrast-enhanced ultrasound (3D-CEUS) volume calculations of focal liver lesions (FLLs).
Thirty-nine patients (15 men and 24 women; mean age, 55.4 years) with 39 FLLs (mean size, 3.1±1.8 cm; size range, 1 to 8 cm) prospectively underwent 3D-CEUS. Four readers calculated the volume of each lesion in an independent and blinded fashion in two separate sessions by means of a semi-automatic, commercially available proprietary software. The differences in lesion volumes (cm3) among sessions and readers were assessed using the Mann-Whitney U test and the Kruskal-Wallis test. Bland-Altman analysis was also performed. Intraclass correlation coefficients (ICCs) with 95% confidence intervals (95% CIs) were calculated. The statistical significance level was set at P<0.05.
Among readers, there were no statistically significant differences in the first (P=0.953) and second (P=0.592) reading sessions for volume calculations of the 39 FLLs, with almost perfect inter-reader agreement (ICC values of the first reading session, 0.996; 95% CI, 0.992 to 0.998 and ICC value of the second reading session, 0.994; 95% CI, 0.990 to 0.997, respectively). For each of the four readers, there were no significant differences in volume calculations between the two sessions (P=0.503-0.924), and the intrareader agreement was almost perfect for each reader (R1: ICC, 0.995; 95% CI, 0.991 to 0.998; R2: ICC, 0.995; 95% CI, 0.988 to 0.997; R3: ICC, 0.996; 95% CI, 0.992 to 0.998; R4: ICC, 0.985; 95% CI, 0.971 to 0.992).
3D-CEUS volume calculations provided consistent measurements across different readers with almost perfect intrareader agreement.
本研究旨在评估三维对比增强超声（3D-CEUS）对肝脏局灶性病变（FLLs）体积计算的观察者间和观察者内一致性。
39例患者（15例男性和24例女性；平均年龄55.4岁），共39个FLLs（平均大小3.1±1.8 cm；大小范围1至8 cm）前瞻性接受3D-CEUS检查。四位阅片者通过半自动、市售的专有软件，在两个独立的时间段内以独立且盲法的方式计算每个病变的体积。使用Mann-Whitney U检验和Kruskal-Wallis检验评估不同时间段和阅片者之间病变体积（cm³）的差异。还进行了Bland-Altman分析。计算了具有95%置信区间（95% CIs）的组内相关系数（ICCs）。统计学显著性水平设定为P<0.05。
在阅片者之间，对于39个FLLs的体积计算，第一次（P=0.953）和第二次（P=0.592）阅片时均无统计学显著差异，阅片者间一致性几乎完美（第一次阅片的ICC值为0.996；95% CI为0.992至0.998，第二次阅片的ICC值为0.994；95% CI为0.990至0.997）。对于四位阅片者中的每一位，两个时间段之间的体积计算均无显著差异（P=0.503 - 0.924），且每位阅片者的观察者内一致性几乎完美（R1：ICC，0.995；95% CI，0.991至0.998；R2：ICC，0.995；95% CI，0.988至0.997；R3：ICC，0.996；95% CI，0.992至0.998；R4：ICC，0.985；95% CI，0.971至0.992）。
3D-CEUS体积计算在不同阅片者之间提供了一致的测量结果，观察者内一致性几乎完美。
