Baenas Nieves, Ruales Jenny, Moreno Diego A, Barrio Daniel Alejandro, Stinco Carla M, Martínez-Cifuentes Gabriela, Meléndez-Martínez Antonio J, García-Ruiz Almudena
Department of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare-Nostrum", University of Murcia, Campus de Espinardo, 30100 Murcia, Spain.
Department of Food Science and Biotechnology, Escuela Politécnica National, Quito 17-01-2759, Ecuador.
Foods. 2020 Oct 17;9(10):1483. doi: 10.3390/foods9101483.
The aim of this study was to evaluate Andean blueberries ( Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC-DAD-MS determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward and in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays.
本研究的目的是评估来自厄瓜多尔的安第斯蓝莓（Kunth）作为食品和制药行业潜在功能成分的可能性。通过HPLC-DAD-MS对生物活性化合物进行分析，确定其（多）酚含量高，主要为花青素，并且存在类胡萝卜素叶黄素。关于其生物学特性，安第斯蓝莓在斑马鱼胚胎发育试验中未显示出毒性，也未检测到抗营养物质凝集素。此外，体外和体内抗氧化能力评估结果表明其有可能用作天然抗氧化剂。这种水果在低剂量下对[具体微生物]也表现出抗菌活性。最后，体外胃肠道（GI）消化显示（多）酚具有部分生物可及性（在最后一步约为50%），在不同胃肠道阶段均表现出高抗氧化能力。这些结果表明安第斯蓝莓是用作功能成分以及开展进一步体内和临床试验的一个有吸引力的候选物。
