Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan.
Department of Psychology, Fo Guang University, Yilan County 26247, Taiwan.
Sensors (Basel). 2020 Oct 16;20(20):5869. doi: 10.3390/s20205869.
The currents of optical stimulation devices with tethered or untethered systems have various disadvantages, including optical fiber breakage, disrupted animal movements, heavy batteries carried on heads, and high-frequency electromagnetic impacts. Our novel wireless remote control was developed to address these issues. The novel wireless device uses a magnetic resonance technique to modify the deficits of the conventional magnetic induction or radio-frequency power sources. The present device emits a strong and steady electromagnetic power. It is cheaper than previous versions, and the receiver coil on its head is very light (≦ 1 g). For the present wireless remote-controlled device, the electromagnetic field's range (i.e., +5 cm and -5 cm of the outside coil) is larger than the range for the magnetic induction and radio-frequency power sources. The present device controls animals' behavior by the electromagnetic field's effective range via photostimulation. The novel wireless remote-controlled device with a magnetic resonance technique can be applied in many behavioral tasks in mice and rats. To avoid the adverse effects of high radio frequency and to extend the electromagnetic field's range, this novel technique serves as a helpful tool to modulate the neuronal activity of target neurons in specific brain areas for optogenetic experiments.
带有系绳或非系绳系统的光刺激设备的电流有各种缺点，包括光纤断裂、动物运动中断、头部携带的重电池以及高频电磁影响。我们开发了新型无线遥控器来解决这些问题。新型无线设备使用磁共振技术来改善传统磁感应或射频电源的缺陷。该新型设备发出强大而稳定的电磁功率。它比以前的版本更便宜，头部的接收线圈非常轻（≦1 克）。对于目前的无线遥控设备，电磁场的范围（即外部线圈的+5 厘米和-5 厘米）大于磁感应和射频电源的范围。目前的设备通过光刺激来控制动物的行为，通过电磁场的有效范围来控制。具有磁共振技术的新型无线遥控器可应用于小鼠和大鼠的许多行为任务中。为了避免高频的不利影响并扩大电磁场的范围，这项新技术可作为一种有用的工具，用于调节特定脑区目标神经元的神经活动，以进行光遗传学实验。
