脾脏对小鼠肺淋巴结反应的调节。
Splenic regulation of the murine pulmonary lymph node response.
作者信息
Allen E M, Abramoff P, Fink J N, Calvanico N J
机构信息
Department of Medicine, Medical College of Wisconsin.
出版信息
Clin Exp Immunol. 1987 Aug;69(2):459-67.
Exposure to intratracheal immunization and aerosolization with soluble antigen plus murmayl-dipeptide (MDP) induces the development of plaque-forming cells in the pulmonary draining lymph nodes of two of three inbred mouse strains. Splenectomy before immunization led to a heightened plaque-forming cell response in the two responder mouse strains. Adoptive transfer of spleen cells from one strain exposed to sperm whale myoglobin via the respiratory tract revealed the presence of antigen-specific suppressor cells. These observations suggest that the spleen may play a role in the down-regulation of an immune response elicited in the pulmonary draining lymph nodes by exposure of the respiratory tract to soluble antigens plus MDP.
经气管内免疫以及用可溶性抗原加胞壁酰二肽（MDP）雾化处理，可在三种近交系小鼠中的两种小鼠的肺引流淋巴结中诱导形成斑块形成细胞。免疫前进行脾切除会导致这两种有反应的小鼠品系中斑块形成细胞反应增强。将经呼吸道接触抹香鲸肌红蛋白的一个品系的脾细胞进行过继转移，结果显示存在抗原特异性抑制细胞。这些观察结果表明，脾脏可能在呼吸道接触可溶性抗原加MDP后，对肺引流淋巴结中引发的免疫反应的下调中发挥作用。
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