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积聚性污染气溶胶的形成会影响肺癌的发病率。

Construction of polluted aerosol in accumulation that affects the incidence of lung cancer.

作者信息

Jenwitheesuk Kriangsak, Peansukwech Udomlack, Jenwitheesuk Kamonwan

机构信息

General Surgery Unit, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Research Manager & Consultant of Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

出版信息

Heliyon. 2020 Feb 8;6(2):e03337. doi: 10.1016/j.heliyon.2020.e03337. eCollection 2020 Feb.

Abstract

BACKGROUND

This model demonstrated the correlation between lung cancer incidences and the parts of ambient air pollution according to the National Aeronautics and Space Administration (NASA)'s high resolution technology satellites.

METHODS

Chemical type of aerosols was investigated by the Aerosol Diagnostics Model such as black carbon, mineral dust, organic carbon, sea-salt and SO4. The model investigated associations between the six year accumulation of each aerosol and lung cancer incidence by Bayesian hierarchical spatio-temporal model. Which also represented integrated geophysical parameters.

RESULTS

In analyses of accumulated chemical aerosol component from 2010 - 2016, the incidence rate ratio (IRR) of patients in 2017 were estimated. We observed a significant increasing risk for organic carbon exposure (IRR 1.021, 95%CI 1.020-1.022), SO, (IRR 1.026, 95% CI 1.025-1.028) and dust, (IRR 1.061, 95% CI 1.058-1.064). There was also suggestion of an increased risk with, every 1 ug/m increase in organic carbon compound is associated with 21% increased risk of lung cancer, whereas a 26% excess risk of cancer per 1 ug/m increase in mean SO and 61% increased risk of lung cancer for dust levels. The other variables were the negative IRR which did not increase the risk of the exposed group.

CONCLUSION

With our results, this process can determine that organic carbon, SO and dust was significantly associated with the elevated risk of lung cancer.

摘要

背景

该模型根据美国国家航空航天局(NASA)的高分辨率技术卫星展示了肺癌发病率与环境空气污染区域之间的相关性。

方法

通过气溶胶诊断模型研究气溶胶的化学类型,如黑碳、矿物粉尘、有机碳、海盐和硫酸盐。该模型通过贝叶斯分层时空模型研究了每种气溶胶六年累积量与肺癌发病率之间的关联,该模型还代表了综合地球物理参数。

结果

在对2010 - 2016年累积化学气溶胶成分的分析中,估计了2017年患者的发病率比(IRR)。我们观察到有机碳暴露(IRR 1.021,95%CI 1.020 - 1.022)、SO(IRR 1.026,95%CI 1.025 - 1.028)和粉尘(IRR 1.061,95%CI 1.058 - 1.064)的风险显著增加。也有迹象表明,有机碳化合物每增加1微克/立方米,肺癌风险增加21%,而平均SO每增加1微克/立方米,癌症额外风险增加26%,粉尘水平导致肺癌风险增加61%。其他变量的IRR为负,未增加暴露组的风险。

结论

根据我们的结果,这一过程可以确定有机碳、SO和粉尘与肺癌风险升高显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71cb/7016011/25e3a0a930bf/gr1.jpg

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