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全身及单光子发射计算机断层扫描/计算机断层扫描成像:以225锕-四氮杂环十二烷四乙酸-奥曲肽作为晚期直肠神经内分泌肿瘤伴转移患者的主要治疗方式的肽受体α放射性核素治疗图像

Whole-body and Single-Photon Emission Computed Tomography/Computed Tomography Postpeptide Receptor Alpha Radionuclide Therapy Images of Actinium 225-Tetraazacyclododecanetetraacetic Acid-Octreotide as a Primary Modality of Treatment in a Patient with Advanced Rectal Neuroendocrine Tumor with Metastases.

作者信息

Kamaleshwaran Koramadai Karuppusamy, Suneelkumar Malipedda, Madhusairam Raghunathan, Radhakrishnan Edathuruthy Kalarikal, Arunpandiyan Soundararajan, Arnold Vasumathi Jayaraj

机构信息

Department of Nuclear Medicine, PET/CT and Radionuclide Therapy, Comprehensive Cancer Care Center, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.

Department of Radiation Oncology, Comprehensive Cancer Care Center, Kovai Medical Center and Hospital Limited, Coimbatore, Tamil Nadu, India.

出版信息

Indian J Nucl Med. 2020 Jul-Sep;35(3):226-228. doi: 10.4103/ijnm.IJNM_58_20. Epub 2020 Jul 1.

Abstract

Somatostatin receptor-targeted alpha radionuclide therapies have been introduced including actinium-225 labeled tetraazacyclododecanetetraacetic acid-octreotide (Ac-225 DOTATATE) for advanced metastatic neuroendocrine tumors (NET). Very limited data are available on the posttherapy imaging using Ac-225 DOTATATE therapy in metastatic NET. We present Ac-225 single-photon emission computed tomography/computed tomography images of a 72-year-old patient diagnosed as a case of advanced rectal NET treated primarily with Ac-225 DOTATATE.

摘要

已引入针对生长抑素受体的α放射性核素疗法,包括用于晚期转移性神经内分泌肿瘤(NET)的锕-225标记的四氮杂环十二烷四乙酸-奥曲肽(Ac-225 DOTATATE)。关于转移性NET中使用Ac-225 DOTATATE治疗后的成像数据非常有限。我们展示了一名72岁患者的Ac-225单光子发射计算机断层扫描/计算机断层扫描图像,该患者被诊断为晚期直肠NET,主要接受Ac-225 DOTATATE治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e36/7537929/16b186f97329/IJNM-35-226-g001.jpg

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