Li Zhifang, Lei Xianlian, Xu Bing, Wang Suyun, Gao Tiantian, Lv Hongmei
Emergency Department, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.
Department of Obstetrics and Gynecology, Jining Maternal and Child Health Family Planning Service Center, Jining, Shandong 272100, P.R. China.
Exp Ther Med. 2020 Dec;20(6):127. doi: 10.3892/etm.2020.9257. Epub 2020 Oct 1.
The aim of the present study was to explore the risk factors of diabetes peripheral neuropathy (DPN) in type 2 diabetes mellitus, and to propose corresponding nursing intervention measures to provide the basis for early diagnosis, treatment and prevention of DPN. A retrospective analysis was performed on 130 patients with type 2 diabetes mellitus (T2DM) in the communities surrounding our hospital from January 2017 to June 2018. They were divided into a DPN group (62 cases) and non-DPN group (control group, 68 cases). First, a univariate analysis was performed. DPN or non-DPN were used as dependent variables, and statistically significant parameters in univariate analysis were used as independent variables. Multivariate logistic regression analysis was included to analyze the peripheral nerves in type 2 diabetes mellitus. At the same time, the patients with DPN were given individualized comprehensive nursing intervention. Univariate analysis showed that body mass index (BMI), diabetes duration, smoking history, drinking history, family history of diabetes, fasting blood glucose (FBG), postprandial blood glucose (PBG), glycosylated hemoglobin (HbA1c), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure, 24-h urine microalbumin excretion (24hmALB), glomerular filtration rate (GFR), serum creatinine in DPN group were significantly different from those in the control group (P<0.05). Logistic regression analysis showed that the duration of diabetes, PBG, glycosylated hemoglobin (HbA1c), HDL-C, 24hmALB, and GFR were independent risk factors for DPN. The quality of life [Physiological function (PF), Role-physical (RP), Role-emotional (RE), General health (GH), Social function (SF), Mental health (MH), Bodily pain (BP), Vitality (VT)] in the DPN group was significantly improved after six months of individualized nursing intervention compared with that before intervention (P<0.05). In conclusion, the high risk factors of DPN should be identified as early as possible, to prevent and delay the occurrence and development of diabetes peripheral neuropathy, so as to improve the quality of life of these patients.
本研究旨在探讨2型糖尿病患者糖尿病周围神经病变（DPN）的危险因素，并提出相应的护理干预措施，为DPN的早期诊断、治疗和预防提供依据。对我院周边社区2017年1月至2018年6月期间的130例2型糖尿病（T2DM）患者进行回顾性分析。将他们分为DPN组（62例）和非DPN组（对照组，68例）。首先进行单因素分析。以DPN或非DPN作为因变量，将单因素分析中有统计学意义的参数作为自变量。纳入多因素logistic回归分析以分析2型糖尿病患者的周围神经情况。同时，对DPN患者给予个体化综合护理干预。单因素分析显示，DPN组的体重指数（BMI）、糖尿病病程、吸烟史、饮酒史、糖尿病家族史、空腹血糖（FBG）、餐后血糖（PBG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、收缩压、24小时尿微量白蛋白排泄量（24hmALB）、肾小球滤过率（GFR）、血清肌酐与对照组相比差异有统计学意义（P<0.05）。logistic回归分析显示，糖尿病病程、PBG、糖化血红蛋白（HbA1c）、HDL-C、24hmALB和GFR是DPN的独立危险因素。经过6个月的个体化护理干预后，DPN组的生活质量[生理功能（PF）、身体角色（RP）、情感角色（RE）、总体健康（GH）、社会功能（SF）、心理健康（MH）、身体疼痛（BP）、活力（VT）]与干预前相比有显著改善（P<0.05）。综上所述，应尽早识别DPN高危因素，预防和延缓糖尿病周围神经病变的发生发展，从而提高这些患者的生活质量。
