Translational and Clinical Research Institute, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL, UK.
Department of Psychiatry, University of Cambridge, Cambridge, UK.
J Neurol. 2021 Apr;268(4):1284-1294. doi: 10.1007/s00415-020-10271-1. Epub 2020 Oct 21.
To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls.
We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative to cerebellum was calculated, and we aimed to examine differences in relative perfusion between MCI-LB and the other groups. This included whole brain voxelwise comparisons, as well as using predefined region-of-interest ratios of medial occipital to medial temporal, and posterior cingulate to precuneus. Differences in occipital perfusion in eyes open vs eyes closed conditions were also examined.
Compared to controls, the MCI-LB showed reduced perfusion in the precuneus, parietal, occipital and fusiform gyrus regions. In our predefined regions, the ratio of perfusion in occipital/medial temporal was significantly lower, and the posterior cingulate/precuneus ratio was significantly higher in MCI-LB compared to controls. Overall, the occipital perfusion was greater in the eyes open vs closed condition, but this did not differ between groups.
We found patterns of altered perfusion in MCI-LB which are similar to those seen in dementia with Lewy bodies, with reduction in posterior parietal and occipital regions, but relatively preserved posterior cingulate.
使用动脉自旋标记技术比较路易体轻度认知障碍（MCI-LB）与阿尔茨海默病型 MCI（MCI-AD）和健康对照组之间的灌注差异。
我们对 32 例 MCI-LB、30 例 MCI-AD 和 28 例年龄相近的健康受试者进行了灌注成像。计算了相对于小脑的灌注，并旨在检查 MCI-LB 与其他组之间相对灌注的差异。这包括全脑体素比较，以及使用内侧枕叶与内侧颞叶和后扣带回与楔前叶的预设感兴趣区域比值。还检查了睁眼与闭眼状态下枕叶灌注的差异。
与对照组相比，MCI-LB 在楔前叶、顶叶、枕叶和梭状回区域的灌注减少。在我们预设的区域中，MCI-LB 中枕叶/内侧颞叶的灌注比值明显降低，后扣带回/楔前叶的比值明显升高。总的来说，睁眼时枕叶的灌注大于闭眼时，但组间无差异。
我们发现 MCI-LB 中存在与路易体痴呆相似的灌注改变模式，后顶叶和枕叶区域减少，但后扣带回相对保留。
