皮拉烷酮和皮拉酮类化合物从. 的果实中。
Pyranoflavanones and Pyranochalcones from the Fruits of .
机构信息
College of Pharmacy , Chungbuk National University , Cheongju 28610 , Korea.
Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology , Korea University , Seoul 02841 , Korea.
出版信息
J Nat Prod. 2019 Jul 26;82(7):1886-1892. doi: 10.1021/acs.jnatprod.9b00155. Epub 2019 Jun 25.
Eight new geranylated and farnesylated pyranoflavanones (-) and two new farnesylated pyranochalcones ( and ) were isolated from the methanolic extract of the fruits of . Their structures were elucidated by extensive analysis of the 1D and 2D NMR spectra and from the HRESIMS, combined with experimental ECD data. All compounds were evaluated for their inhibitory effects on the nitric oxide production against lipopolysaccharide-induced RAW 264.7 macrophages and exhibited IC values ranging from 10.6 to 41.5 μM.
从 果实的甲醇提取物中分离得到了 8 个新的香叶基和法呢基吡喃黄酮（(-)）和 2 个新的法呢基吡喃查尔酮（和）。通过对 1D 和 2D NMR 光谱的广泛分析以及结合实验 ECD 数据，确定了它们的结构。所有化合物都评估了对脂多糖诱导的 RAW 264.7 巨噬细胞一氧化氮产生的抑制作用，其 IC 值范围为 10.6 至 41.5 μM。
Zotero 插件