State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, People's Republic of China.
Jiangsu Second Normal University, Nanjing 210013, People's Republic of China.
Langmuir. 2020 Nov 3;36(43):12983-12989. doi: 10.1021/acs.langmuir.0c02288. Epub 2020 Oct 21.
Indocyanine green (ICG) is a near-infrared (NIR) fluorescent dye for extensive biomedical application. However, its fluorescence intensity is limited by its poor aqueous stability and concentration-dependent aggregation. To overcome these limitations, ICG self-assembled nanobubbles (ICG-NBs) with an average size of 244.6 nm are fabricated. In the ICG-NB assembled structures, the ICG molecules are arrayed on the gas-liquid interface by the hydrophobic interaction with the gas core and hydrophilic heads with water. Results show that ICG-NBs exhibited good monodispersity and excellent fluorescence and size stability. Compared with ICG solution, the ICG-NBs indicate the enhanced quantum yield and fluorescence intensity. The surface-enhanced Raman scattering (SERS) spectra and fluorescence lifetime measurement demonstrate that the ICG molecule assembled NBs could result in the changes of molecular vibration and time-resolved intensity decays of ICG. Thus, the ICG-NBs could be more beneficial for optical imaging in clinical applications in the future.
吲哚菁绿（ICG）是一种近红外（NIR）荧光染料，广泛应用于生物医学领域。然而，其荧光强度受到其较差的亲水性和浓度依赖性聚集的限制。为了克服这些限制，我们制备了平均粒径为 244.6nm 的 ICG 自组装纳米气泡（ICG-NBs）。在 ICG-NB 组装结构中，ICG 分子通过与气体核心的疏水相互作用和与水的亲水头部在气液界面上排列。结果表明，ICG-NBs 表现出良好的单分散性和优异的荧光和尺寸稳定性。与 ICG 溶液相比，ICG-NBs 表现出增强的量子产率和荧光强度。表面增强拉曼散射（SERS）光谱和荧光寿命测量表明，ICG 分子组装的 NBs 可导致 ICG 分子振动和时间分辨强度衰减的变化。因此，ICG-NBs 未来可能更有益于临床应用中的光学成像。
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