Boettcher F A, Henderson D, Gratton M A, Danielson R W, Byrne C D
Callier Center for Communication Disorders, University of Texas, Dallas.
Ear Hear. 1987 Aug;8(4):192-212. doi: 10.1097/00003446-198708000-00003.
The following is a review of the literature on interaction of noise and other agents, both ototraumatic and nonototraumatic. A short description of the anatomical effects of exposure to intense sound previews the interaction literature. The effects of exposure to combinations of continuous and impulse noise are discussed. This is followed by a review of data on interactions of noise and ototoxic drugs and noise and whole-body vibration, including discussion of putative mechanisms of synergism. In addition, preliminary results of noise-cisplatinum interaction are presented which suggest that if cisplatinum is presented during noise exposure in dose schedules simulating human chemotherapy schedules, hearing threshold shifts and histological damage is much greater than that caused by either agent in isolation. The clinical relevance of the interactions is discussed, along with potential synergistic interactions not yet investigated.
以下是关于噪声与其他因素（包括耳外伤和非耳外伤因素）相互作用的文献综述。对暴露于高强度声音的解剖学效应进行简短描述，为相互作用文献做铺垫。讨论了暴露于连续噪声和脉冲噪声组合的影响。接下来是关于噪声与耳毒性药物以及噪声与全身振动相互作用的数据综述，包括对协同作用假定机制的讨论。此外，还给出了噪声与顺铂相互作用的初步结果，表明如果在模拟人类化疗方案的剂量安排下，在噪声暴露期间给予顺铂，听力阈值变化和组织学损伤比单独使用任何一种药物所引起的要大得多。文中讨论了这些相互作用的临床相关性，以及尚未研究的潜在协同相互作用。
