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B细胞特异性莫洛尼鼠白血病病毒插入位点1促进涎腺腺样囊性癌的侵袭、转移及预后不良。

B-cell specific Moloney murine leukemia virus insertion site 1 contributes to invasion, metastasis, and poor prognosis in salivary adenoid cystic carcinoma.

作者信息

Wang Rongyan, Zhu Fangyong, Gao Guilin, Gong Zhongjian, Yin Zhiguo, Ren Wei, Wang Xin, Liu Yang, Wang Shigang, Wu Xiangbing

机构信息

Department of Stomatology, Affiliated Children's Hospital of Jiangnan University, Wuxi, China.

Department of Stomatology, Affiliated Hospital of Jiangnan University, Wuxi, China.

出版信息

J Dent Sci. 2024 Jan;19(1):21-31. doi: 10.1016/j.jds.2023.06.014. Epub 2023 Jun 24.

DOI:10.1016/j.jds.2023.06.014
PMID:38303897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10829681/
Abstract

BACKGROUND/PURPOSE: Upregulation of B-cell specific Moloney murine leukemia virus insertion site 1 (BMI-1) has been involved in the invasion, metastasis, and poor prognosis of many cancers. The aim of this study was to evaluate the levels and clinical significance of BMI-1 in saliva of patients with salivary adenoid cystic carcinoma (SACC), and to analyze biological function and mechanism of BMI-1 in the invasion and metastasis of SACC.

MATERIALS AND METHODS

The levels of BMI-1 in saliva and tumor tissues of SACC patients were determined. The correlation of salivary BMI-1 levels with clinicopathological parameters and clinical outcomes in patients with SACC was analyzed. Additionally, the effects of BMI-1 on wound-healing, transwell invasion, and epithelial-mesenchymal transition (EMT)-related protein expression as well as on tumorigenicity and experimental lung metastasis were investigated through exogenous overexpression and silencing of BMI-1 in SACC cells.

RESULTS

BMI-1 levels increased in saliva and tumor tissues in SACC patients with invasion or metastasis. High salivary BMI-1 levels were correlated with poor TNM stage, poor overall survival, and disease-free survival. Exogenous expression of BMI-1 in SACC-83 promoted its migration and invasion, while silencing BMI-1 in SACC-LM inhibited its migration and invasion and suppressed tumorigenesis and lung metastasis . Furthermore, BMI-1 regulated the expression of EMT-related proteins in SACC.

CONCLUSION

Our study shows that BMI-1 can serve as a valuable biomarker to identify tumor invasion and metastasis in SACC, predict its prognosis, and act as a promising therapeutic target for SACC.

摘要

背景/目的：B细胞特异性莫洛尼鼠白血病病毒插入位点1（BMI-1）的上调与多种癌症的侵袭、转移及不良预后有关。本研究旨在评估涎腺腺样囊性癌（SACC）患者唾液中BMI-1的水平及其临床意义，并分析BMI-1在SACC侵袭和转移中的生物学功能及机制。

材料与方法

测定SACC患者唾液和肿瘤组织中BMI-1的水平。分析SACC患者唾液中BMI-1水平与临床病理参数及临床结局的相关性。此外，通过在SACC细胞中外源过表达和沉默BMI-1，研究BMI-1对伤口愈合、Transwell侵袭、上皮-间质转化（EMT）相关蛋白表达以及对致瘤性和实验性肺转移的影响。

结果

有侵袭或转移的SACC患者唾液和肿瘤组织中BMI-1水平升高。唾液中BMI-1水平高与TNM分期差、总生存期和无病生存期差相关。在SACC-83中外源表达BMI-1促进其迁移和侵袭，而在SACC-LM中沉默BMI-1则抑制其迁移和侵袭，并抑制致瘤性和肺转移。此外，BMI-1调节SACC中EMT相关蛋白的表达。

结论

我们的研究表明，BMI-1可作为一种有价值的生物标志物，用于识别SACC中的肿瘤侵袭和转移、预测其预后，并作为SACC有前景的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/e1fa4fa0e1b4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/4c1289b55294/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/67ec8d5c333c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/89b5ed5ca3c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/37c282f75764/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/d82cae33926e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/5de4aff319bc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/e1fa4fa0e1b4/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/4c1289b55294/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/67ec8d5c333c/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/89b5ed5ca3c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/37c282f75764/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/d82cae33926e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/5de4aff319bc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c55b/10829681/e1fa4fa0e1b4/gr7.jpg

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