Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Ciudad de México 11340, Mexico.
Licenciatura en Nutrición, Universidad Intercontinental, Insurgentes Sur 4303, Santa Úrsula Xitla, Alcaldía Tlalpan, Ciudad de México 14420, Mexico.
Int J Mol Sci. 2020 Oct 19;21(20):7724. doi: 10.3390/ijms21207724.
(1) Background: Regular exercise induces physiological and morphological changes in the organisms, but excessive training loads may induce damage and impair recovery or muscle growth. The purpose of the study was to evaluate the impact of Silymarin (SM) consumption on endurance capacity, muscle/cardiac histological changes, bodyweight, and food intake in rats subjected to 60 min of regular exercise training (RET) five days per week. (2) Methods: Male Wistar rats were subjected to an eight-week RET treadmill program and were previously administered SM and vitamin C. Bodyweight and food consumption were measured and registered. The maximal endurance capacity (MEC) test was performed at weeks one and eight. After the last training session, the animals were sacrificed, and samples of quadriceps/gastrocnemius and cardiac tissue were obtained and process for histological analyzes. (3) Results: SM consumption improved muscle recovery, inflammation, and damaged tissue, and promoted hypertrophy, vascularization, and muscle fiber shape/appearance. MEC increased after eight weeks of RET in all trained groups; moreover, the SM-treated group was enhanced more than the group with vitamin C. There were no significant changes in bodyweight and in food and nutrient consumption along the study. (5) Conclusion: SM supplementation may enhance physical performance, recovery, and muscle hypertrophy during the eight-week RET program.
（1）背景：规律运动可引起机体的生理和形态变化，但过大的训练负荷可能会导致损伤，从而影响恢复或肌肉生长。本研究旨在评估水飞蓟素（SM）的摄入对经过每周 5 天、每天 60 分钟常规运动训练（RET）的大鼠的耐力、肌肉/心脏组织学变化、体重和食物摄入的影响。（2）方法：雄性 Wistar 大鼠进行了为期 8 周的 RET 跑步机训练计划，并在之前给予了 SM 和维生素 C。测量并记录体重和食物摄入量。在第 1 周和第 8 周进行最大耐力能力（MEC）测试。在最后一次训练结束后，处死动物，获得股四头肌/腓肠肌和心脏组织样本，并进行组织学分析。（3）结果：SM 摄入可改善肌肉恢复、炎症和受损组织，并促进肥大、血管生成和肌纤维形态/外观。所有训练组在经过 8 周的 RET 后 MEC 均增加，而经 SM 处理的组比经维生素 C 处理的组增加更多。在整个研究过程中，体重以及食物和营养物质的摄入均无明显变化。（5）结论：SM 补充可能会增强 8 周 RET 计划期间的身体表现、恢复和肌肉肥大。
