水飞蓟素补充剂对啮齿动物模型运动训练期间肺和肝脏组织学改变的影响。

Effect of Silymarin Supplementation in Lung and Liver Histological Modifications during Exercise Training in a Rodent Model.

作者信息

Vargas-Mendoza Nancy, Angeles-Valencia Marcelo, Morales-González Ángel, Morales-Martínez Mauricio, Madrigal-Bujaidar Eduardo, Álvarez-González Isela, Fregoso-Aguilar Tomás, Delgado-Olivares Luis, Madrigal-Santillán Eduardo Osiris, Morales-González José A

机构信息

Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Casco de Santo Tomás, Del. Miguel Hidalgo, Ciudad de México 11340, Mexico.

Escuela Superior de Cómputo, Instituto Politécnico Nacional, Av. Juan de Dios Bátiz s/n Esquina Miguel Othón de Mendizabal, Unidad Profesional Adolfo López Mateos, Ciudad de México 07738, Mexico.

出版信息

J Funct Morphol Kinesiol. 2021 Aug 30;6(3):72. doi: 10.3390/jfmk6030072.

DOI:10.3390/jfmk6030072

PMID:34564191

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8482127/

Abstract

BACKGROUND

Exercise training induces adaptive physiological and morphological modifications in the entire organism; however, excessive loads of training may increase damage in tissues. The purpose of this study was to evaluate the effect of silymarin in lung and liver histological changes in rats subjected to exercise training (ET).

METHODS

Male Wistar rats were subjected to an 8-week ET treadmill program 5 days per week, 60 min/session, and were previously administered 100 mg ascorbic acid or 100 mg of silymarin.

RESULTS

Silymarin increased alveolar and bronchial muscle size, improve vascularization, and reduced tissue inflammation. In liver, silymarin promoted the reduction of lipid content.

CONCLUSION

Silymarin supplementation may improve inflammation in pulmonary tissue after 8 weeks of the ET treadmill program, improve cell recovery, and reduce intrahepatic lipid content.

摘要