Department of Colorectal Surgery, S. Rita Clinic, Vercelli, Italy.
Rev Recent Clin Trials. 2021;16(1):87-90. doi: 10.2174/1574887115666201021150144.
Hemorrhoids are vascular cushions underlying the distal rectal mucosa and contributing to approximately 15-20% of the resting anal pressure with a complete closure of the anal canal. They can become pathological (hemorrhoidal disease, HD) being the most common cause of painless rectal bleeding during defecation with or without prolapsing anal tissue. The treatment of HD must be tailored to both the severity of disease and patient's expectation.
A narrative review of all the most relevant papers present on the three major databases (PUBMED, EMBASE and WEB OF SCIENCE) regarding conservative treatment was conducted.
Conservative treatment is effective in managing the majority of patients complaining of early stages of the disease. Dietary and lifestyle modifications are the first therapeutic step necessary to achieve a regular defecation with soft stool whereas oral phlebotonic drugs can help to control symptoms. The use of topical medications, particularly during the acute phase or in the post-operative period can also be beneficial for all patients complaining of HD.
Despite a large number of available products in the market and the high incidence of HD, very few randomized controlled trials have been carried out and most of the studies are uncontrolled case series. Larger and better designed studies are necessary to establish the real benefit of all types of drugs for the treatment of early stages of HD.
痔疮是位于直肠远端黏膜下的血管垫,约占肛管静息压的 15-20%,对肛管完全关闭起重要作用。它们可能会发生病理性改变(痔病,HD),是排便时无痛性直肠出血的最常见原因,伴有或不伴有脱垂的肛门组织。HD 的治疗必须针对疾病的严重程度和患者的期望进行调整。
对 PUBMED、EMBASE 和 WEB OF SCIENCE 这三个主要数据库中所有关于保守治疗的最相关论文进行了综述。
保守治疗对大多数患有早期疾病的患者有效。饮食和生活方式的改变是实现定期排便和软便的必要的第一步,而口服静脉活性药物可以帮助控制症状。局部用药的使用,特别是在急性阶段或术后期间,也对所有患有 HD 的患者有益。
尽管市场上有大量的产品,HD 的发病率也很高,但只有少数随机对照试验已经进行,而且大多数研究都是非对照病例系列。需要进行更大和设计更好的研究,以确定所有类型的药物治疗 HD 早期阶段的真正益处。