饮食相关酸负荷与结直肠癌和腺瘤风险的病例对照研究。
Diet-dependent acid load and the risk of colorectal cancer and adenoma: a case-control study.
机构信息
Student Research Committee, Department and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Public Health Nutr. 2021 Oct;24(14):4474-4481. doi: 10.1017/S1368980020003420. Epub 2020 Oct 22.
OBJECTIVES
Colorectal cancer (CRC) is the third and second most prevalent cancer in men and women, respectively. Various epidemiological studies indicated that dietary factors are implicated in the aetiology of CRC and its precursor, colorectal adenomas (CRA). Recently, much attention has been given to the role of acid-base balance in the development of chronic diseases including cancers. Therefore, the aim of the current study is to examine the association of diet-dependent acid load and the risk of CRC and CRA.
DESIGN
In this case-control study, potential renal acid load (PRAL) was computed based on dietary intake of participants assessed via a validated FFQ. Negative PRAL values indicated a base-forming potential, while positive values of PRAL implied acid-forming potential of diet. Logistic regression was used to derive OR and 95 % CI after adjusting for confounders.
SETTING
Tehran, Iran.
PARTICIPANTS
A total of 499 participants aged 30-70 years were included in the study (240 hospital controls, 129 newly diagnosed CRC and 130 newly diagnosed CRA). The current study was conducted between December 2016 and September 2018.
RESULTS
After adjusting for potential confounders, a higher PRAL was associated with increased odds of CRC and CRA. The highest v. the lowest tertile of PRAL for CRC and CRA was OR 4·82 (95 % CI 2·51-9·25) and OR 2·47 (95 % CI 1·38-4·42), respectively.
CONCLUSIONS
The findings of the current study suggested that higher diet-dependent acid load is associated with higher risk of CRC and CRA.
目的
结直肠癌（CRC）分别是男性和女性中第三和第二常见的癌症。各种流行病学研究表明，饮食因素与 CRC 及其前体结直肠腺瘤（CRA）的发病机制有关。最近，人们对酸碱平衡在包括癌症在内的慢性疾病发展中的作用给予了极大关注。因此，本研究旨在探讨饮食相关酸负荷与 CRC 和 CRA 风险之间的关联。
设计
在这项病例对照研究中，根据通过验证的 FFQ 评估的参与者的饮食摄入量计算潜在肾酸负荷（PRAL）。负 PRAL 值表示形成碱的潜力，而 PRAL 的正值表示饮食形成酸的潜力。在调整混杂因素后，使用逻辑回归得出 OR 和 95%CI。
地点
伊朗德黑兰。
参与者
共有 499 名年龄在 30-70 岁的参与者（240 名医院对照者、129 名新诊断的 CRC 和 130 名新诊断的 CRA）纳入了本研究。本研究于 2016 年 12 月至 2018 年 9 月进行。
结果
在调整潜在混杂因素后，较高的 PRAL 与 CRC 和 CRA 的患病风险增加相关。CRC 和 CRA 的 PRAL 最高与最低三分位相比，OR 分别为 4.82（95%CI 2.51-9.25）和 2.47（95%CI 1.38-4.42）。
结论
本研究结果表明，较高的饮食相关酸负荷与 CRC 和 CRA 的风险增加有关。
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