XRCC1- 协调和组装多功能 DNA 损伤反应的策略。
XRCC1 - Strategies for coordinating and assembling a versatile DNA damage response.
机构信息
Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, 111 T. W. Alexander Dr, NC, 27709, United States.
出版信息
DNA Repair (Amst). 2020 Sep;93:102917. doi: 10.1016/j.dnarep.2020.102917.
Abstract
X-ray cross complementing protein 1 (XRCC1) is a DNA repair scaffold that supports base excision repair and single strand break repair, and is also a participant in other repair pathways. It also serves as an important co-transporter for several other repair proteins, including aprataxin and PNKP-like factor (APLF), and DNA Ligase 3α (LIG3). By combining highly specialized regions that help to organize specific repair functions with recruitment of additional enzymes whose contribution is dependent on the details of the damaged site, XRCC1 is able to handle an expanded range of problems that may arise as the repair progresses or in connection with other repair pathways with which it interfaces. This review discusses the interplay between these functions and considers some possible interactions that underlie its reported repair activities.
摘要
X 射线交错互补蛋白 1（XRCC1）是一种 DNA 修复支架，支持碱基切除修复和单链断裂修复，也是其他修复途径的参与者。它还是几种其他修复蛋白（包括 aprataxin 和 PNKP 样因子（APLF）和 DNA 连接酶 3α（LIG3）的重要共转运蛋白。通过结合有助于组织特定修复功能的高度专业化区域，以及招募额外的酶，其贡献取决于受损部位的细节，XRCC1 能够处理随着修复的进行或与它接口的其他修复途径可能出现的一系列扩展问题。本综述讨论了这些功能之间的相互作用，并考虑了一些可能的相互作用，这些相互作用是其报道的修复活动的基础。
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