Licciardello J T, Moake J L, Rudy C K, Karp D D, Hong W K
Oncology. 1985;42(5):296-300. doi: 10.1159/000226049.
Factor-VIII-related von Willebrand factor (vWF) multimers are synthesized by endothelial cells, and plasma vWF antigen levels are elevated in some disorders associated with endothelial cell perturbation. We studied 13 patients during cisplatin-based combination chemotherapy for squamous cell carcinoma of the head and neck, esophagus, or lung. Before therapy, 3 of the patients had vWF antigen levels that were greater than or equal to 400% of normal; and further elevations occurred during chemotherapy. Two of these patients had cerebrovascular accidents, and the third had complications similar to the hemolytic-uremic and acute respiratory distress syndromes. No abnormalities in plasma vWF patterns were detected. Elevated plasma vWF antigen levels before therapy may identify a subgroup of patients at special risk for arterial occlusive complications following cisplatin-based chemotherapy.
与因子VIII相关的血管性血友病因子（vWF）多聚体由内皮细胞合成，在一些与内皮细胞紊乱相关的疾病中，血浆vWF抗原水平会升高。我们研究了13例接受基于顺铂的联合化疗的头颈部、食管或肺癌鳞状细胞癌患者。治疗前，3例患者的vWF抗原水平大于或等于正常水平的400%；化疗期间进一步升高。其中2例患者发生脑血管意外，第3例患者出现类似于溶血尿毒症和急性呼吸窘迫综合征的并发症。未检测到血浆vWF模式异常。治疗前血浆vWF抗原水平升高可能识别出一组在基于顺铂的化疗后有动脉闭塞并发症特殊风险的患者。
