Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Sci Rep. 2020 Oct 21;10(1):17907. doi: 10.1038/s41598-020-72993-6.
Coffee consumption has been associated with the risk of cancer at several anatomical sites, but the findings, mostly from studies of non-Hispanic whites and Asians, are inconsistent. The association between coffee consumption and the incidence of cancer has not been thoroughly examined in African Americans. We conducted a nested case-control study including 1801 cancer cases and 3337 controls among African Americans from the Southern Community Cohort Study (SCCS) to examine the association between coffee drinking, as assessed by a semi-quantitative food frequency questionnaire, and the risk of four common cancers (lung, prostate, breast, colorectal). We used logistic regression adjusted for age, sex and cancer-specific risk factors. Overall, only ≤ 9.5% of African American cases and controls from the SCCS drank regular or decaffeinated coffee ≥ 2 times/day. After adjustment for major cancer-specific risk factors, coffee consumption was not statistically significantly associated with the risk of lung, breast, colorectal, or prostate cancers (OR range 0.78-1.10; P ≥ 0.27 for ≥ 2 versus < 1 times/day) or overall cancer risk (OR 0.93; 95% CI 0.75-1.16; P = 0.52 for ≥ 2 versus < 1 times/day). Coffee consumption was not associated with the risk of cancer among African Americans in our study.
咖啡消费与几种解剖部位的癌症风险有关，但这些发现主要来自对非西班牙裔白人和亚洲人的研究，结果并不一致。在非裔美国人中，咖啡消费与癌症发病率之间的关联尚未得到彻底研究。我们进行了一项嵌套病例对照研究，纳入了来自南方社区队列研究（SCCS）的 1801 例癌症病例和 3337 例对照，以研究通过半定量食物频率问卷评估的咖啡饮用与四种常见癌症（肺癌、前列腺癌、乳腺癌、结直肠癌）风险之间的关系。我们使用逻辑回归调整了年龄、性别和特定癌症风险因素。总体而言，SCCS 中只有 ≤ 9.5%的非裔美国癌症病例和对照每天饮用普通或脱咖啡因咖啡 ≥ 2 次。在调整了主要的特定癌症风险因素后，咖啡消费与肺癌、乳腺癌、结直肠癌或前列腺癌的风险（OR 范围 0.78-1.10；P ≥ 0.27 对于每天饮用 ≥ 2 次与 < 1 次）或总体癌症风险（OR 0.93；95%CI 0.75-1.16；P = 0.52 对于每天饮用 ≥ 2 次与 < 1 次）均无统计学显著相关性。在我们的研究中，咖啡消费与非裔美国人的癌症风险无关。
