Kim Sung Hoon, Song Bong-Il, Kim Hae Won, Won Kyoung Sook
Department of Nuclear Medicine, Keimyung University Daegu Dongsan Hospital, Daegu, South Korea.
Department of Nuclear Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, 1095 Dalgubeol-daero, Dalseo-gu, Daegu, 42601 Republic of Korea.
Nucl Med Mol Imaging. 2020 Oct;54(5):233-240. doi: 10.1007/s13139-020-00661-8. Epub 2020 Aug 13.
This study aimed to evaluate the concordance and equivalence of results between the newly acquired digital PET/CT(dPET) and the standard PET/CT (sPET) to investigate possible differences in visual and semi-quantitative analyses.
A total of 30 participants were enrolled and underwent a single F-FDG injection followed by dual PET/CT scans, by a dPET scan, and immediately after by the sPET scan or vice versa. Two readers reviewed overall image quality using a 5-point scale and counted the number of suggestive F-FDG avid lesions. The SUV values were measured in the background organs and in hypermetabolic target lesions. Additionally, we objectively evaluated image quality using the liver signal-to-noise ratio (SNR).
The dPET identified 4 additional F-FDG avid lesions in 3 of 30 participants with improved visual image quality. The standard deviations of SUV of the background organs were significantly lower with Digital than with sPET, and dPET could acquire images with better SNR (11.13 ± 2.01 vs. 8.71 ± 1.32, < 0.001). The reliability of SUV values between scanners showed excellent agreement. Bland-Altman plot analysis of 81 lesions showed an acceptable agreement between scanners for most of the SUVmax and SUVpeak values. No relationship between the SUV values and time delays of dual PET/CT acquisition was found.
The dPET provides improved image quality and lesion detectability than the sPET. The semi-quantitative values of the two PET/CT systems of different vendors are comparable. This pilot study will be an important basis for possible interchangeable use of either system in clinical practice.
本研究旨在评估新购置的数字正电子发射断层显像/计算机断层扫描（dPET）与标准正电子发射断层显像/计算机断层扫描（sPET）结果的一致性和等效性，以研究视觉和半定量分析中可能存在的差异。
共纳入30名参与者，单次注射F-FDG后进行两次正电子发射断层显像/计算机断层扫描，先进行dPET扫描，随后立即进行sPET扫描，或反之。两名阅片者使用5分制评估整体图像质量，并计数可疑的F-FDG摄取病变数量。在背景器官和高代谢靶病变中测量标准化摄取值（SUV）。此外，我们使用肝脏信噪比（SNR）客观评估图像质量。
dPET在30名参与者中的3名中发现了4个额外的F-FDG摄取病变，视觉图像质量有所改善。背景器官SUV的标准差在数字系统中显著低于sPET，且dPET能够获取具有更好SNR的图像（11.13±2.01对8.71±1.32，<0.001）。扫描仪之间SUV值的可靠性显示出极好的一致性。对81个病变的Bland-Altman图分析显示，扫描仪之间对于大多数SUVmax和SUVpeak值具有可接受的一致性。未发现SUV值与正电子发射断层显像/计算机断层扫描双时相采集时间延迟之间的关系。
与sPET相比，dPET提供了更好的图像质量和病变可检测性。不同厂家的两种正电子发射断层显像/计算机断层扫描系统的半定量值具有可比性。这项初步研究将成为两种系统在临床实践中可能互换使用的重要依据。
