Giannini A J, Folts D J, Feather J N, Sullivan B S
Northeastern Ohio University College of Medicine, Columbus.
Psychiatry Res. 1989 Jul;29(1):11-6. doi: 10.1016/0165-1781(89)90182-0.
The effects of bromocriptine and amantadine in treating cocaine withdrawal were compared. Withdrawal symptoms are thought to be due to central dopamine depletion. Both bromocriptine and amantadine are dopamine agonists previously reported to diminish withdrawal symptoms. Thirty subjects were withdrawn for 30 days with amantadine, bromocriptine, or placebo. Bromocriptine and amantadine were more effective than placebo for 15 days. Amantadine's effectiveness then declined so that it was no more effective than placebo by experiment's end. Bromocriptine was significantly more effective than both throughout the latter phase of the study. Amantadine's decline in effectiveness is hypothesized to be due to stimulation of dopamine release.
比较了溴隐亭和金刚烷胺治疗可卡因戒断的效果。戒断症状被认为是由于中枢多巴胺耗竭所致。溴隐亭和金刚烷胺均为多巴胺激动剂，此前有报道称它们可减轻戒断症状。30名受试者分别使用金刚烷胺、溴隐亭或安慰剂进行为期30天的戒断治疗。溴隐亭和金刚烷胺在15天内比安慰剂更有效。随后金刚烷胺的有效性下降，到实验结束时其效果已不比安慰剂更好。在研究的后期阶段，溴隐亭比两者都显著更有效。据推测，金刚烷胺有效性的下降是由于刺激了多巴胺释放。
