Kranzler H R, Bauer L O
Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030.
Br J Addict. 1992 Nov;87(11):1537-48. doi: 10.1111/j.1360-0443.1992.tb02661.x.
Based on previous reports that bromocriptine, a postsynaptic dopamine agonist, reduced cocaine craving and prevented relapse in cocaine-dependent subjects, effects of the drug were evaluated in 20 cocaine-dependent males in an inpatient drug rehabilitation programme. The subjective and physiologic effects of exposure to both cocaine-associated and neutral stimuli, presented using videotapes, were measured at one-week intervals. Between laboratory sessions subjects received either bromocriptine (1.25 mg bid) or a matched placebo, administered in double-blind fashion. Compared with the neutral videotape, the cocaine videotape elicited both a greater desire to use cocaine and more symptoms associated with cocaine self-administration. These results support an appetitive conditioning model of cocaine effects. Bromocriptine, however, had no effect on the cocaine-cue-associated reactivity, which declined over the 1-week interval in both treatment groups. Methodological differences among studies that have examined the effects of bromocriptine in cocaine-dependent subjects may explain the variable findings observed.
基于之前的报道，即突触后多巴胺激动剂溴隐亭可减少可卡因成瘾者对可卡因的渴望并预防复发，在一项住院药物康复项目中，对20名可卡因成瘾男性进行了该药物效果的评估。使用录像带呈现可卡因相关刺激和中性刺激，每隔一周测量接触这些刺激后的主观和生理效应。在各实验阶段之间，受试者以双盲方式接受溴隐亭（1.25毫克，每日两次）或匹配的安慰剂。与中性录像带相比，可卡因录像带既引发了更强烈的使用可卡因的欲望，也引发了更多与可卡因自我给药相关的症状。这些结果支持了可卡因效应的诱因条件反射模型。然而，溴隐亭对与可卡因线索相关的反应性没有影响，在两个治疗组中，这种反应性在1周的间隔内均有所下降。研究溴隐亭对可卡因成瘾者影响的研究之间的方法学差异，可能解释了所观察到的不同结果。
