Hoesly J M, Mertz L E, Winkelmann R K
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
J Am Acad Dermatol. 1987 Sep;17(3):455-8. doi: 10.1016/s0190-9622(87)70229-1.
Enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA) were performed in 25 and 32 cases of morphea, respectively. The more sensitive and specific ELISA was positive in only 1 of 25 cases and the mean value was lower in cases of morphea than in controls. IFA showed minimally reactive titers in 6 (19%) of 32 cases. There were an additional six cases with borderline titers. These data indicate that there is no specific association between Borrelia burgdorferi infection and morphea but that patients with morphea tend to have circulating antibodies that are cross-reactive.
分别对25例硬斑病患者和32例硬斑病患者进行了酶联免疫吸附测定（ELISA）和免疫荧光测定（IFA）。更敏感和特异的ELISA在25例中仅1例呈阳性，硬斑病患者的平均值低于对照组。IFA显示32例中有6例（19%）反应滴度极低。另外有6例滴度处于临界值。这些数据表明，伯氏疏螺旋体感染与硬斑病之间没有特异性关联，但硬斑病患者往往有交叉反应的循环抗体。
