Department of Respiratory Medicine, National Center for Geriatrics and Gerontology, Obu, Japan.
Department of Nursing, National Center for Geriatrics and Gerontology, Obu, Japan.
Clin Respir J. 2021 Feb;15(2):216-224. doi: 10.1111/crj.13287. Epub 2020 Dec 9.
This study examined the possible associations between frailty and patient-reported outcomes (PROs) in elderly patients with asthma.
Participants completed the Kihon Checklist for frailty screening as well as the following tools for measuring generic- and disease-specific health-related quality of life (HRQOL) and asthma control; the Medical Outcomes Study 36-item short form (SF-36), the Hyland Scale (global scale), the Asthma Quality of Life Questionnaire (AQLQ), the Asthma Control Test (ACT), and the Asthma Control Questionnaire (ACQ).
Of 69 consecutive outpatients with asthma, 38 (55.1%), 21 (30.4%), and 10 (14.5%) were classified as robust, pre-frail, and frail, respectively. Eight out of 52 patients with asthma in the elderly (AIE) (>65 years old) (15.4%) were considered as being frail. The Kihon Checklist total score was significantly correlated with all the scores obtained from the SF-36, Hyland Scale, AQLQ, ACT, and ACQ. All these scores were significantly different between groups with and without frailty. From the viewpoint of correlation coefficient, SF-36 Physical Functioning correlated most strongly with a coefficient of -0.68 (P < .01), and the Hyland Scale score was second (R = -0.46, P < .01). The correlations between the Kihon Checklist total score and lung function parameters were weak or negative (|R | < 0.35).
There were significant associations between frailty and PROs, particularly generic perception of HRQOL. Since the Kihon Checklist and PROs such as the HRQOL overlap somewhat in their evaluation of the patients' condition, there might be some similarities in the conceptual frameworks of frailty and quality of life.
本研究旨在探讨老年哮喘患者衰弱与患者报告结局（PROs）之间可能存在的关联。
参与者完成了 Kihon 衰弱筛查清单以及以下用于测量一般和疾病特异性健康相关生活质量（HRQOL）和哮喘控制的工具：医疗结局研究 36 项简短表格（SF-36）、Hyland 量表（总量表）、哮喘生活质量问卷（AQLQ）、哮喘控制测试（ACT）和哮喘控制问卷（ACQ）。
在 69 名连续的哮喘门诊患者中，分别有 38 名（55.1%）、21 名（30.4%）和 10 名（14.5%）被归类为健壮、衰弱前期和衰弱。在 52 名（15.4%）年龄较大（>65 岁）的哮喘患者中，有 8 名被认为是衰弱的。Kihon Checklist 总分与 SF-36、Hyland 量表、AQLQ、ACT 和 ACQ 获得的所有评分显著相关。在有和没有衰弱的患者之间，所有这些评分均有显著差异。从相关系数的角度来看，SF-36 身体机能与相关性最强，相关系数为-0.68（P <.01），Hyland 量表得分为次（R = -0.46，P <.01）。Kihon Checklist 总分与肺功能参数之间的相关性较弱或为负（|R | < 0.35）。
衰弱与 PROs 之间存在显著关联，特别是对一般 HRQOL 的感知。由于 Kihon Checklist 和 PROs （如 HRQOL）在评估患者病情方面存在一定程度的重叠，因此衰弱和生活质量的概念框架可能存在一些相似之处。
