Department of Cardiology and Cardiovascular Medicine, University Clinic, Eberhard Karls-University Tübingen, Germany; Section for Cardioimmunology, Inflammatory Cardiovascular Diseases, Eberhard Karls-University Tübingen, Germany.
Department of Cardiology and Cardiovascular Medicine, University Clinic, Eberhard Karls-University Tübingen, Germany; Section for Cardioimmunology, Inflammatory Cardiovascular Diseases, Eberhard Karls-University Tübingen, Germany.
Semin Immunol. 2018 Jun;37:43-52. doi: 10.1016/j.smim.2018.01.003. Epub 2018 Feb 6.
The complement system is a versatile part of our immune system. Various intersection points of complement with other cells and molecules of the immune response are well described. Platelets are classically conceived as cells of hemostasis. In recent years, however, several functions of platelets "beyond thrombosis" were discovered. This review depicts the crosstalk of platelets with components of the immune system in the context of thrombo-inflammation. In particular, the various ways, in which platelets interact with the complement system, are illustrated. Platelets cannot only aggravate vascular inflammation and cardiovascular diseases, but they also contribute to organ remodeling and tissue homeostasis. Here, we portray the role of complement factors associated with platelet activation in tissue remodeling. Importantly, the clinical relevance of this platelet-complement crosstalk is addressed. A focus lies on thrombo-inflammatory disorders, other diseases with thrombo-embolic mechanisms or complications, but also autoimmune diseases. Finally, we draw attention to the growing body of evidence on the role of complement-platelet crosstalk in cardiovascular diseases. For future clinical, translational and basic science approaches, this crosstalk may prove a fruitful area of research in order to procure novel therapeutic and diagnostic targets in cardiovascular medicine and previously less addressed diseases featuring a platelet-complement axis.
补体系统是我们免疫系统的一个多功能部分。补体与免疫反应的其他细胞和分子的各种交叉点得到了很好的描述。血小板通常被认为是止血细胞。然而，近年来，人们发现了血小板的几种“超越血栓形成”的功能。这篇综述描述了血栓炎症背景下血小板与免疫系统成分的串扰。特别是，说明了血小板与补体系统相互作用的各种方式。血小板不仅可以加重血管炎症和心血管疾病，还可以促进器官重塑和组织内稳态。在这里，我们描述了与血小板激活相关的补体因子在组织重塑中的作用。重要的是，还解决了这种血小板-补体相互作用的临床相关性。重点放在血栓炎症性疾病、具有血栓栓塞机制或并发症的其他疾病上，但也包括自身免疫性疾病。最后，我们提请注意越来越多的证据表明补体-血小板相互作用在心血管疾病中的作用。对于未来的临床、转化和基础科学方法，这种相互作用可能证明是一个富有成效的研究领域，以获得心血管医学和以前较少涉及血小板-补体轴的疾病的新的治疗和诊断靶点。
