White Patricia M
Department of Neuroscience, Ernest J. Del Monte Institute for Neuroscience, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA.
Brain Sci. 2020 Oct 20;10(10):756. doi: 10.3390/brainsci10100756.
Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration. Birds and fish can spontaneously regenerate lost hair cells through a process that has become better defined in the last few years. Findings from these studies have informed new research on hair cell regeneration in the mammalian cochlea. Hair cell regeneration is one part of the greater problem of hearing restoration, as hearing loss can stem from a myriad of causes. This review discusses these issues and recent findings, and places them in the greater social context of need and community.
大多数后天性听力损失的成年人发现，这是一种目前的假肢难以有效矫正的残疾。这种差距推动了目前关于耳蜗机械感觉毛细胞再生和听力恢复的研究。鸟类和鱼类可以通过一种在过去几年中已得到更清晰界定的过程自发地再生失去的毛细胞。这些研究的结果为哺乳动物耳蜗毛细胞再生的新研究提供了信息。毛细胞再生只是听力恢复这一更大问题的一部分，因为听力损失可能源于无数原因。这篇综述讨论了这些问题和最新发现，并将它们置于需求和社区的更广泛社会背景中。
