Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, ICDDRB, Dhaka, Bangladesh.
Department of Zoology, University of Dhaka, Dhaka, Bangladesh.
BMJ Open Gastroenterol. 2020 Oct;7(1). doi: 10.1136/bmjgast-2020-000490.
Over the last few years, epidemiological studies have shown that infection with has a major effect on micronutrient deficiency as well as on adverse pregnancy outcomes. Importantly, there are gaps in understanding the linkage of infection with micronutrients deficiency in pregnant women.
We conducted a systematic review and meta-analysis to estimate the association between infection and micronutrient deficiencies in pregnant women.
A systematic literature search was conducted for relevant articles using PubMed, Web of Science, and Scopus database from inception to March 2020. The OR with 95% CIs was determined by meta-analysis of data extracted from the selected studies.
From 2384 primary articles, 6 studies were selected for systematic reviews and 4 studies distinctively (with 1274 participants: 553 cases and 721 controls) were selected for meta-analysis. The meta-analysed fixed effect model estimated the odds of having infection was not significantly higher among pregnant women with micronutrient deficiencies than those without deficiencies (OR=1.12, 95% CI 0.88 to 1.42, p=0.37). In the subgroup analysis, no correlation was found between infection and vitamin B (OR=0.74, 95% CI 0.45 to 1.21, p=0.22), folate (OR=1.07, 95% CI 0.73 to 1.58, p=0.73), and ferritin (OR=0.81, 95% CI 0.51 to 1.31, p=0.4). However, a positive correlation was found between iron-deficiency anaemia (IDA) and infection (OR=16.23, 95% CI 4.19 to 62.93, p<0.0001) during pregnancy.
infection is associated with increased risk of IDA but not with deficiency of other micronutrients in pregnancy.
CRD42019135683.
在过去的几年中，流行病学研究表明，感染 会对微量营养素缺乏以及不良妊娠结局产生重大影响。重要的是，人们对 感染与孕妇微量营养素缺乏之间的联系认识不足。
我们进行了系统评价和荟萃分析，以评估 感染与孕妇微量营养素缺乏之间的关系。
从 2020 年 3 月开始，使用 PubMed、Web of Science 和 Scopus 数据库对相关文献进行了系统检索。通过对入选研究中提取的数据进行荟萃分析，确定 OR 及其 95%CI。
从 2384 篇原始文章中，选择了 6 篇进行系统评价，4 篇（共 1274 名参与者：553 例病例和 721 例对照）进行荟萃分析。荟萃分析的固定效应模型估计，与没有缺乏的孕妇相比，有微量营养素缺乏的孕妇感染 的几率没有显著升高（OR=1.12，95%CI 0.88 至 1.42，p=0.37）。在亚组分析中，未发现 感染与维生素 B（OR=0.74，95%CI 0.45 至 1.21，p=0.22）、叶酸（OR=1.07，95%CI 0.73 至 1.58，p=0.73）和铁蛋白（OR=0.81，95%CI 0.51 至 1.31，p=0.4）之间存在相关性。然而，在怀孕期间发现缺铁性贫血（IDA）与 感染之间存在正相关（OR=16.23，95%CI 4.19 至 62.93，p<0.0001）。
感染与妊娠期 IDA 风险增加相关，但与其他微量营养素缺乏无关。
PROSPERO 注册号：CRD42019135683。
