Department of Urology, University of Michigan, 1500 E. Medical Center Drive, TC 3875 SPC 5330, Ann Arbor, MI, 48109, USA.
Drugs Aging. 2021 Jan;38(1):1-16. doi: 10.1007/s40266-020-00810-w. Epub 2020 Oct 23.
In this review, the current literature regarding pharmacotherapy treatment strategies available for the management of interstitial cystitis/bladder pain syndrome in older adults is addressed. The focus is on those treatments described by the American Urologic Association guidelines, organized according to clinical phenotype. Symptoms at presentation can vary with age, with older adults being more likely to experience nocturia, urinary incontinence, and Hunner's lesions than their younger counterparts. As such, treatment of interstitial cystitis/bladder pain syndrome should follow an individualized multimodal plan based on the patient's unique phenotype(s), starting with the most conservative options and escalating as needed. The side-effect profile and medication interactions should be reviewed, especially when treating older adults, requesting the aid of pharmacists or the primary care physician as needed to safely provide treatment.
在这篇综述中，探讨了目前可用于治疗老年间质性膀胱炎/膀胱疼痛综合征的药物治疗策略。重点关注美国泌尿科协会指南中描述的那些治疗方法，并根据临床表型进行组织。临床表现的症状可能随年龄而变化，老年人比年轻人更有可能出现夜尿、尿失禁和 Hunner 病变。因此，间质性膀胱炎/膀胱疼痛综合征的治疗应根据患者独特的表型（s）制定个体化的多模式计划，从最保守的选择开始，并根据需要逐步升级。应审查副作用谱和药物相互作用，特别是在治疗老年人时，必要时应请求药剂师或初级保健医生的帮助，以安全地提供治疗。
