长链非编码 RNA 在适应性免疫中的作用：在生理和病理条件下的作用。
LncRNAs in adaptive immunity: role in physiological and pathological conditions.
机构信息
Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
出版信息
RNA Biol. 2021 May;18(5):619-632. doi: 10.1080/15476286.2020.1838783. Epub 2020 Nov 9.
The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NFκB, MYC, interferon and TCR/BCR signalling (), and cell effector functions (). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration.
适应性免疫系统负责产生免疫应答和免疫记忆。适应性免疫的调节包括 B 细胞和 T 细胞生物学，主要从蛋白质和 microRNA 的角度来理解。然而，长非编码 RNA（lncRNA）是一类新兴的非编码 RNA（ncRNA），它影响淋巴细胞生物学中的关键因素，如 NOTCH、PAX5、MYC 和 EZH2。lncRNA 通过调节 NFAT、NFκB、MYC、干扰素和 TCR/BCR 信号转导等途径来调节淋巴细胞的激活（），并调节细胞效应功能（）。在这里，我们回顾了 lncRNA 在适应性免疫中的作用及其对自身免疫性疾病（多发性硬化症、炎症性肠病、类风湿性关节炎）和 T/B 细胞白血病和淋巴瘤（CLL、MCL、DLBCL、T-ALL）的影响。越来越明显的是，lncRNA 在适应性免疫反应中很重要，并为其协调提供了新的见解。
Zotero 插件