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Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease.

作者信息

Rab Minke A E, Kanne Celeste K, Bos Jennifer, van Oirschot Brigitte A, Boisson Camille, Houwing Maite E, Gerritsma Jorn, Teske Erik, Renoux Celine, Riedl Jurgen, Schutgens Roger E G, Bartels Marije, Nur Erfan, Joly Philippe, Fort Romain, Cnossen Marjon H, van Wijk Richard, Connes Philippe, van Beers Eduard J, Sheehan Vivien A

机构信息

Central Diagnostic Laboratory-Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

出版信息

Am J Hematol. 2021 Jan;96(1):E29-E32. doi: 10.1002/ajh.26031. Epub 2020 Nov 11.

DOI:10.1002/ajh.26031
PMID:33095451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7756395/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e7c/7756395/c727d03fc6f2/AJH-96-E29-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e7c/7756395/c727d03fc6f2/AJH-96-E29-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e7c/7756395/c727d03fc6f2/AJH-96-E29-g001.jpg

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本文引用的文献

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Am J Hematol. 2019 May;94(5):575-584. doi: 10.1002/ajh.25443. Epub 2019 Mar 8.
2
Measuring success: utility of biomarkers in sickle cell disease clinical trials and care.衡量成功：生物标志物在镰状细胞病临床试验和护理中的应用。
Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):482-492. doi: 10.1182/asheducation-2018.1.482.
3
A Phase 3 Trial of l-Glutamine in Sickle Cell Disease.
将镰状细胞血红蛋白（HbS）碱基编辑为马卡萨血红蛋白（HbG-Makassar）可改善血红蛋白功能，支持其在镰状细胞病中的应用。
Nat Commun. 2025 Feb 7;16(1):1441. doi: 10.1038/s41467-025-56578-3.
4
Multicenter, phase 1 study of etavopivat (FT-4202) treatment for up to 12 weeks in patients with sickle cell disease.多中心、1 期研究评估 etavopivat（FT-4202）治疗镰状细胞病患者长达 12 周的疗效。
Blood Adv. 2024 Aug 27;8(16):4459-4475. doi: 10.1182/bloodadvances.2023012467.
5
A novel composition of endogenous metabolic modulators improves red blood cell properties in sickle cell disease.一种新型内源性代谢调节剂组合物可改善镰状细胞病中的红细胞特性。
EJHaem. 2024 Feb 2;5(1):21-32. doi: 10.1002/jha2.850. eCollection 2024 Feb.
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Oxygen gradient ektacytometry-derived biomarkers are associated with acute complications in sickle cell disease.氧梯度 ektacytometry 衍生的生物标志物与镰状细胞病的急性并发症相关。
Blood Adv. 2024 Jan 23;8(2):276-286. doi: 10.1182/bloodadvances.2023011013.
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