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In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension.

作者信息

Agarwal Stuti, de Jesus Perez Vinicio A

机构信息

Divisions of Pulmonary and Critical Care Medicine and.

The Vera Moulton Wall Center for Pulmonary Vascular Medicine Stanford University Stanford, California.

出版信息

Am J Respir Crit Care Med. 2021 Mar 1;203(5):541-542. doi: 10.1164/rccm.202009-3706ED.

DOI:10.1164/rccm.202009-3706ED
PMID:33095993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7924564/
Abstract
摘要

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Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.NUDT1介导的氧化型DNA前体清除作用对肺动脉高压血管重塑的影响
Am J Respir Crit Care Med. 2021 Mar 1;203(5):614-627. doi: 10.1164/rccm.202003-0627OC.
2
Participation of PLK1 and FOXM1 in the hyperplastic proliferation of pulmonary artery smooth muscle cells in pulmonary arterial hypertension.PLK1 和 FOXM1 参与肺动脉高血压中肺动脉平滑肌细胞的过度增生。
PLoS One. 2019 Aug 22;14(8):e0221728. doi: 10.1371/journal.pone.0221728. eCollection 2019.
3
Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension.导致肺动脉高压中持续激活的细胞表型的机制。
J Physiol. 2019 Feb;597(4):1103-1119. doi: 10.1113/JP275857. Epub 2018 Aug 7.
4
(S)-crizotinib reduces gastric cancer growth through oxidative DNA damage and triggers pro-survival akt signal.(S)-克唑替尼通过氧化 DNA 损伤减少胃癌生长，并触发促生存 akt 信号。
Cell Death Dis. 2018 May 31;9(6):660. doi: 10.1038/s41419-018-0667-x.
5
Oxidative Stress in the Lung - The Essential Paradox.肺部的氧化应激——基本矛盾
Curr Opin Toxicol. 2018 Feb;7:37-43. doi: 10.1016/j.cotox.2017.09.001. Epub 2017 Sep 19.
6
FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension.FOXM1 促进肺动脉高血压中的肺动脉平滑肌细胞扩张。
J Mol Med (Berl). 2018 Feb;96(2):223-235. doi: 10.1007/s00109-017-1619-0. Epub 2017 Dec 30.
7
Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs.肺动脉高压领域的转化研究进展。从癌症生物学到新的肺动脉高压治疗方法。靶向细胞生长和增殖信号枢纽。
Am J Respir Crit Care Med. 2017 Feb 15;195(4):425-437. doi: 10.1164/rccm.201606-1226PP.
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Redox biology in pulmonary arterial hypertension (2013 Grover Conference Series).肺动脉高压中的氧化还原生物学（2013年格罗弗会议系列）
Pulm Circ. 2015 Dec;5(4):599-609. doi: 10.1086/683814.
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Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension.全外显子组测序揭示 TopBP1 是特发性肺动脉高压的一个新基因。
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