在阿尔茨海默病小鼠模型中肝脏 MAIT 细胞的富集。
Enrichment of liver MAIT cells in a mouse model of Alzheimer's disease.
机构信息
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America.
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, United States of America.
出版信息
J Neuroimmunol. 2024 May 15;390:578332. doi: 10.1016/j.jneuroim.2024.578332. Epub 2024 Mar 21.
Emerging evidence has supported a role for the immune system and liver in Alzheimer's disease (AD). However, our understanding of how hepatic immune cells are altered in AD is limited. We previously found that brain mucosal-associated invariant T (MAIT) cell numbers are increased in AD. Furthermore, loss of MAIT cells and their antigen-presenting molecule, MR1, reduced amyloid-β accumulation in the brain. MAIT cells are also significantly present in the liver. Therefore, we sought to analyze MAIT and other immune cells in the AD liver. Increased frequency of activated MAIT cells (but not conventional T cells) were found in 8-month-old 5XFAD mouse livers. Therefore, these data raise the possibility that there is a role for peripheral MAIT cells in AD pathology.
越来越多的证据支持免疫系统和肝脏在阿尔茨海默病（AD）中的作用。然而，我们对 AD 中肝免疫细胞如何发生改变的理解有限。我们之前发现，大脑粘膜相关不变 T（MAIT）细胞数量在 AD 中增加。此外，MAIT 细胞及其抗原呈递分子 MR1 的缺失减少了大脑中的淀粉样蛋白-β积累。MAIT 细胞在肝脏中也大量存在。因此，我们试图分析 AD 肝脏中的 MAIT 和其他免疫细胞。在 8 月龄 5XFAD 小鼠肝脏中发现活化的 MAIT 细胞（而非常规 T 细胞）的频率增加。因此，这些数据提出了外周 MAIT 细胞在 AD 病理中的可能作用。
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