Fawzy Marwa M, Abdel Hay Rania, Mohammed Faisal Nouredin, Sayed Khadiga S, Ghanem Mona El Desoky, Ezzat Marwa
Dermatology Department, Faculty of Medicine, Cairo University, New Cairo, Egypt.
Department of Dermatology and Venereology, National Research Centre, Giza, Egypt.
J Cosmet Dermatol. 2021 Jun;20(6):1827-1836. doi: 10.1111/jocd.13739. Epub 2020 Oct 13.
Trichoscopy is a useful tool for diagnosis and follow-up of alopecia areata (AA) patients. Both platelet-rich plasma (PRP) and intralesional corticosteroids (ILCs) are important treatment modalities of patchy AA.
Trichoscopic diagnosis of AA and monitoring the treatment response to PRP versus ILCs in patchy AA treatment.
PATIENTS/METHODS: This comparative study included 31 patients with patchy AA, divided into two groups: (group A) received ILCs while (group B) received PRP once monthly for 3 months. Evaluation was done by Severity of Alopecia Tool (SALT) score, Alopecia Areata Symptom Impact Scale (AASIS), photography, and dermoscopy.
There was a significant improvement in trichoscopic findings in both groups with regard to the number of follicular units per opening, black dots, broken hairs, and dystrophic changes. Final SALT score showed significant lower levels in both groups compared to baseline levels (P = .025 & P = .008). Final AASIS showed significant decrease in group B (P = .006) not in group A (P = .062).
Trichoscopy can help in the diagnosis, evaluation of the efficacy and safety of both modalities and might give a clue for treatment response. Both ILCs and PRP were effective in patchy AA treatment.
毛发镜检查是斑秃（AA）患者诊断和随访的有用工具。富血小板血浆（PRP）和皮损内注射皮质类固醇（ILC）都是斑秃的重要治疗方式。
通过毛发镜检查诊断斑秃，并监测PRP与ILC治疗斑秃的疗效。
患者/方法：这项比较性研究纳入了31例斑秃患者，分为两组：（A组）接受皮损内注射皮质类固醇，（B组）每月接受一次PRP治疗，共3个月。通过斑秃严重程度工具（SALT）评分、斑秃症状影响量表（AASIS）、摄影和皮肤镜检查进行评估。
两组在毛囊单位开口数量、黑点、断发和营养不良变化等毛发镜检查结果方面均有显著改善。最终SALT评分显示两组均显著低于基线水平（P = 0.025和P = 0.008）。最终AASIS显示B组显著降低（P = 0.006），A组未显著降低（P = 0.062）。
毛发镜检查有助于诊断，评估两种治疗方式的疗效和安全性，并可能为治疗反应提供线索。皮损内注射皮质类固醇和PRP在斑秃治疗中均有效。
