Sanpaolo Eliana Rita, Rotondo Cinzia, Cici Daniela, Corrado Ada, Cantatore Francesco Paolo
Department of Medical and Surgical Sciences, Rheumatology Clinic, University of Foggia Medical School, Foggia, Italy.
Mol Biol Rep. 2020 Nov;47(11):9087-9096. doi: 10.1007/s11033-020-05910-9. Epub 2020 Oct 24.
JAK/STAT signaling pathway is involved in many diseases, including autoimmune diseases, which are characterized by a close interconnection between immune and bone system. JAK/STAT pathway is involved in bone homeostasis and plays an important role in proliferation and differentiation of some cell types, including osteoblasts and osteoclasts. Different molecules, such as cytokines, hormones, and growth factors are responsible for the activation of the JAK/STAT pathway, which leads, at the nuclear level, to start DNA transcription of target genes. Bone cells and remodeling process are often influenced by many cytokines, which act as strong stimulators of bone formation and resorption. Our aim, through careful research in literature, has been to provide an overview of the role of the JAK/STAT pathway in bone remodeling and on bone cells, with a focus on cytokines involved in bone turnover through this signal cascade. The JAK/STAT pathway, through the signal cascade activation mediated by the interaction with many cytokines, acts on bone cells and appears to be involved in bone remodeling process. However, many other studies are needed to completely understand the molecular mechanism underlying these bone process.
JAK/STAT信号通路涉及多种疾病，包括自身免疫性疾病，其特征是免疫和骨骼系统之间存在紧密的相互联系。JAK/STAT通路参与骨稳态，并在包括成骨细胞和破骨细胞在内的某些细胞类型的增殖和分化中发挥重要作用。不同的分子，如细胞因子、激素和生长因子，负责激活JAK/STAT通路，这在核水平上导致靶基因的DNA转录开始。骨细胞和重塑过程常受多种细胞因子影响，这些细胞因子是骨形成和吸收的强大刺激物。我们的目标是通过对文献的仔细研究，概述JAK/STAT通路在骨重塑和骨细胞中的作用，重点关注通过该信号级联参与骨转换的细胞因子。JAK/STAT通路通过与多种细胞因子相互作用介导的信号级联激活，作用于骨细胞，似乎参与骨重塑过程。然而，需要许多其他研究来完全理解这些骨过程背后的分子机制。
