Li Zhiyuan, Dai Xueyan, Yang Fan, Zhao Weina, Xiong Zhiwei, Wan Wengen, Wu Guoyun, Xu Tianfang, Cao Huabin
Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, China.
Jiangxi Agricultural Technology Extension Center, Nanchang, China.
Front Microbiol. 2025 May 13;16:1480077. doi: 10.3389/fmicb.2025.1480077. eCollection 2025.
Composite probiotics are characterized by their non-resistance, no residues, non-toxic effects, and pollution-free nature. To investigate their application capability in piglets, this study aims to explore the effects of composite probiotics on the growth performance and related physiological indicators of piglets.
Sixteen 30-day-old healthy weaned "Duroc × Landrace × Large White" piglets were randomly divided into a control group and a composite probiotic (CP) group. The CP group was supplemented with 2 mg·kg-1 of composite probiotics in the basal diet. After 120 days, the growth performance, serum biochemical parameters, hepatic hormones, and expression levels of JAK2/STAT5 signaling pathway-related factors were measured in each group.
The average daily gain of piglets in the CP group significantly increased, and the feed conversion ratio significantly decreased ( < 0.05). Among the serum biochemical parameters, the levels of triglyceride (TG), aspartate aminotransferase (AST), total cholesterol (TC), and alanine aminotransferase (ALT) were all elevated. Additionally, the levels of growth hormone, insulin, thyroid-stimulating hormone, and triiodothyronine also significantly increased. Furthermore, the addition of composite probiotics upregulated the expression levels of GHR, JAK2, STAT3, STAT5a, and STAT5b.
In conclusion, composite probiotics effectively promote the growth performance of piglets by activating the JAK2/STAT5 signaling pathway. These findings provide a theoretical basis for the application of composite probiotics in piglet feeding.
复合益生菌具有无抗性、无残留、无毒副作用和无污染的特点。为了研究其在仔猪中的应用能力，本研究旨在探讨复合益生菌对仔猪生长性能及相关生理指标的影响。
将16头30日龄健康断奶的“杜洛克×长白×大白”仔猪随机分为对照组和复合益生菌（CP）组。CP组在基础日粮中添加2 mg·kg-1复合益生菌。120天后，测定每组仔猪的生长性能、血清生化参数、肝脏激素以及JAK2/STAT5信号通路相关因子的表达水平。
CP组仔猪平均日增重显著增加，饲料转化率显著降低（P＜0.05）。血清生化参数中，甘油三酯（TG）、天冬氨酸转氨酶（AST）、总胆固醇（TC）和丙氨酸转氨酶（ALT）水平均升高。此外，生长激素、胰岛素、促甲状腺激素和三碘甲状腺原氨酸水平也显著升高。此外，添加复合益生菌上调了GHR、JAK2、STAT3、STAT5a和STAT5b的表达水平。
综上所述，复合益生菌通过激活JAK2/STAT5信号通路有效促进仔猪生长性能。这些研究结果为复合益生菌在仔猪饲养中的应用提供了理论依据。
