Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, 10117 Berlin, Germany.
German Rheumatism Research Centre (DRFZ) Berlin, a Leibniz Institute, 10117 Berlin, Germany.
Int J Mol Sci. 2020 Nov 26;21(23):9004. doi: 10.3390/ijms21239004.
The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signaling pathway serves as an important downstream mediator for a variety of cytokines, hormones, and growth factors. Emerging evidence suggests JAK/STAT signaling pathway plays an important role in bone development, metabolism, and healing. In this light, pro-inflammatory cytokines are now clearly implicated in these processes as they can perturb normal bone remodeling through their action on osteoclasts and osteoblasts at both intra- and extra-articular skeletal sites. Here, we summarize the role of JAK/STAT pathway on development, homeostasis, and regeneration based on skeletal phenotype of individual JAK and STAT gene knockout models and selective inhibition of components of the JAK/STAT signaling including influences of JAK inhibition in osteoclasts, osteoblasts, and osteocytes.
Janus 激酶 (JAK) 信号转导子和转录激活子 (STAT) 信号通路是多种细胞因子、激素和生长因子的重要下游介质。新出现的证据表明，JAK/STAT 信号通路在骨骼发育、代谢和愈合中起着重要作用。在这方面，促炎细胞因子现在显然与这些过程有关，因为它们可以通过作用于关节内和关节外骨骼部位的破骨细胞和成骨细胞来扰乱正常的骨重塑。在这里，我们根据单个 JAK 和 STAT 基因敲除模型的骨骼表型以及 JAK/STAT 信号传导成分的选择性抑制（包括 JAK 抑制对破骨细胞、成骨细胞和骨细胞的影响），总结 JAK/STAT 通路在发育、动态平衡和再生中的作用。
