"Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania.
J BUON. 2020 Jul-Aug;25(4):2117-2122.
Multiple primary neoplasms (MPN) have a growing impact in the outcome of oncological patients given the rising incidence of these entities in daily practice. The early diagnosis of secondary tumors could translate into better survival of patients with MPN. The final objective of this study was the elaboration of a follow-up protocol for oncological patients at risk of developing multiple primary neoplasms.
Patients with MPN diagnosed and treated in the Oncology Institute "Prof.Dr.Ion Chiricuta" Cluj-Napoca (OICN) between 2008-2012 were included in this nonrandomized, retrospective study and the clinicopathological characteristics of these patients and the prognostic factors possibly involved in the occurrence of MPN were analyzed.
278 patients with MPN were included in this study. The median age at diagnosis was 60 years. The median interval between the diagnosis of the primary and secondary neoplasm was 30.98 months. Smoking and alcohol consumption were the most frequent environmental factors observed in patients with MPN. Patients diagnosed with breast cancers, head and neck cancers, colorectal cancer, prostate cancer, ovarian cancer or uterine body cancer were the patients with the highest risk of developing MPN.
This first follow-up protocol for oncological patients at risk of developing multiple primary neoplasms could be implemented in daily practice with further validation of the protocol.
鉴于这些实体在日常实践中的发病率不断上升，多发性原发性肿瘤（MPN）对肿瘤患者的预后产生了越来越大的影响。继发性肿瘤的早期诊断可能会转化为提高 MPN 患者的生存率。本研究的最终目的是制定一种针对有发生多发性原发性肿瘤风险的肿瘤患者的随访方案。
本非随机回顾性研究纳入了 2008 年至 2012 年在克卢日-纳波卡肿瘤研究所“Prof.Dr.Ion Chiricuta”（OICN）诊断和治疗的 MPN 患者，并分析了这些患者的临床病理特征以及可能涉及 MPN 发生的预后因素。
本研究纳入了 278 例 MPN 患者。诊断时的中位年龄为 60 岁。首次原发性和继发性肿瘤诊断之间的中位间隔为 30.98 个月。吸烟和饮酒是 MPN 患者中最常见的环境因素。被诊断患有乳腺癌、头颈部癌症、结直肠癌、前列腺癌、卵巢癌或子宫体癌的患者发生 MPN 的风险最高。
该首个针对有发生多发性原发性肿瘤风险的肿瘤患者的随访方案可在日常实践中实施，并进一步验证该方案。
