Robinson E, Neugut A I
Northern Israel Oncology Center, Rambam Medical Center, Haifa, Israel.
Cancer Detect Prev. 1989;13(5-6):287-92.
We review the medical literature for the clinical characteristics of patients developing multiple primary neoplasms (MPN). Also, preliminary results of our study at Memorial Sloan Kettering Cancer Center are reported. Although there have been very few specific reports on this topic, it was possible to find some data, suggesting a worse prognosis for patients with MPN. Several factors may be responsible for this, and further studies are in progress. Meanwhile, it is of great importance to decrease the incidence of cancer by prevention, such as reducing smoking and alcohol consumption. This may reduce the incidence of first primary neoplasms and MPN. Optimal treatment for the first primary neoplasm should be given, but the possible risk of MPN should be taken into consideration, and, if there are two alternatives for the treatment of the first tumor, the one that is less carcinogenic and that will allow appropriate therapy for a second primary neoplasm (MPN2) should be chosen. On follow-up of cancer patients, a low threshold of suspicion for a second primary neoplasm is recommended to detect them early for possible curative treatment. Because of the poor prognosis, more aggressive treatment regimens for MPN are warranted.
我们查阅医学文献以了解发生多原发性肿瘤（MPN）患者的临床特征。此外，还报告了我们在纪念斯隆凯特琳癌症中心的研究初步结果。尽管关于该主题的具体报告非常少，但仍有可能找到一些数据，提示MPN患者预后较差。可能有几个因素导致这种情况，进一步的研究正在进行中。与此同时，通过预防措施降低癌症发病率非常重要，例如减少吸烟和饮酒。这可能会降低首例原发性肿瘤和MPN的发病率。应给予首例原发性肿瘤最佳治疗，但应考虑到发生MPN的可能风险，并且，如果首例肿瘤有两种治疗方案可供选择，应选择致癌性较低且能为第二原发性肿瘤（MPN2）提供适当治疗的方案。在癌症患者随访中，建议对第二原发性肿瘤保持较低的怀疑阈值，以便早期发现并进行可能的治愈性治疗。由于预后较差，有必要对MPN采取更积极的治疗方案。
