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新型冠状病毒肺炎诊所的医疗管理

Medical management of COVID-19 clinic.

作者信息

Mehta Neha, Qiao Renli

机构信息

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

出版信息

J Biomed Res. 2020 Sep 30;34(6):416-421. doi: 10.7555/JBR.34.20200118.

DOI:10.7555/JBR.34.20200118
PMID:33100274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7718071/
Abstract

The start of the global pandemic secondary to the novel SARS-CoV-2 virus was a time of uncertainty and fear as it claimed the lives of many across the world. Since then, there has been a plethora of research designs and trials in order to understand what we can do to stop the spread of the disease. Scientists and health care providers have utilized old medications and revamped them for current use such a convalescent plasma and steroids, as well as creating novel therapeutics, some with promising results. In this article, we review the major therapeutic options currently available and look into what the future still holds in order to further our understanding of this mysterious disease.

摘要

由新型SARS-CoV-2病毒引发的全球大流行开始之际,是一个充满不确定性和恐惧的时期,因为它夺走了世界各地许多人的生命。从那时起,为了弄清楚我们能做些什么来阻止疾病传播,出现了大量的研究设计和试验。科学家和医疗保健提供者利用了旧药物并对其进行改进以供当前使用,如康复血浆和类固醇,同时也研发了新型疗法,其中一些取得了有希望的成果。在本文中,我们回顾了目前可用的主要治疗选择,并探究未来还有哪些可能,以便进一步加深我们对这种神秘疾病的理解。

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本文引用的文献

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The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020.2019新型冠状病毒病(COVID-19)疫情的流行病学特征 - 中国,2020年
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Tocilizumab in patients with severe COVID-19: a retrospective cohort study.托珠单抗治疗重症新型冠状病毒肺炎患者:一项回顾性队列研究
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Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use Among Outpatients Diagnosed With COVID-19.COVID-19 门诊患者中血管紧张素转换酶抑制剂和血管紧张素 II 受体阻滞剂的使用情况。
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Is hydroxychloroquine beneficial for COVID-19 patients?羟氯喹对 COVID-19 患者有益吗?
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Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19.羟氯喹、阿奇霉素和联合治疗 COVID-19 住院患者。
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Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion.恢复期血浆输注后重症或危重症 COVID-19 患者的临床症状和死亡率改善。
Blood. 2020 Aug 6;136(6):755-759. doi: 10.1182/blood.2020007079.
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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2.一种中和性人源抗体结合到了 SARS-CoV-2 的刺突蛋白的 N 端结构域。
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