Abo ElNaga Heba H, AbdelHalim Hesham A, Abdellatif Mohamed, Bg Haroun, Elnagdy Basem, Ashraf Taghreed, ElNaggar Bahaa, S Eldin Passant, Ta Ismail, Mosaad Beshoy, Ismail Tasbeeha, Boules Rasmy, Methuselah Shawky, Rafaat Paula
Pulmonary Medicine Department, Faculty of Medicine, October 6 University, Giza, Egypt.
Pulmonary Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Open Respir Med J. 2021 Nov 10;15:46-51. doi: 10.2174/1874306402115010046. eCollection 2021.
Fever, cough, fatigue, and myalgia are usually the original clinical picture of the COVID-19 pandemic, which appears non-specific and not exclusive.
To illustrate the clinical picture pattern and assess the prevalence of underlying co-morbidities and their correlation with the severity of COVID-19 infected patients.
A cross-sectional online survey included 580 participants who were either suspected or confirmed with COVID-19 infection.
The severity of the disease significantly correlates with both age (p=.01) and the time lag of the diagnosis of COVID-19 (p=.03). Hypertension (p=.015) and diabetes mellitus (p<.01) were significantly associated with the duration of symptoms. A wide range of ages (21-60 years) seemed to be the only risk factor for the severity. When symptoms were tested, dyspnea appeared to be the most prevalent symptom, predicting a more severe disease (OR= .066, 95% CI: .022- .200), followed by diarrhea (OR= .285, 95% CI: .122-.663), then fever (OR= .339, 95% CI: .139-.824). During the examination of co-morbidities influences on the severity, the only major co-morbidity that predicted a more severe disease was IHD (OR= .218, 95% CI: .073- .648), p= .006.
Special consideration is required for patients with COVID-19 with an associated longer gap between symptoms and diagnosis and associated co-morbidities including hypertension, diabetes, and established chronic kidney disease (CKD), for which this study proved its profound influence on the severity of the illness and duration of symptoms.
发热、咳嗽、乏力和肌痛通常是新冠疫情最初的临床表现，这些表现并无特异性且并非新冠所特有。
阐述临床表现模式，并评估新冠感染患者潜在合并症的患病率及其与疾病严重程度的相关性。
一项横断面在线调查纳入了580名疑似或确诊新冠感染的参与者。
疾病严重程度与年龄（p = 0.01）和新冠确诊时间间隔（p = 0.03）均显著相关。高血压（p = 0.015）和糖尿病（p < 0.01）与症状持续时间显著相关。广泛的年龄范围（21至60岁）似乎是疾病严重程度的唯一风险因素。对症状进行检测时，呼吸困难似乎是最常见的症状，预示疾病更严重（OR = 0.066，95% CI：0.022 - 0.200），其次是腹泻（OR = 0.285，95% CI：0.122 - 0.663），然后是发热（OR = 0.339，95% CI：0.139 - 0.824）。在检查合并症对疾病严重程度的影响时，唯一能预测疾病更严重的主要合并症是缺血性心脏病（OR = 0.218，95% CI：0.073 - 0.648），p = 0.006。
对于新冠患者，若症状与诊断之间的间隔时间较长且存在包括高血压、糖尿病和已确诊的慢性肾脏病（CKD）在内的合并症，需要给予特别关注，本研究证明这些合并症对疾病严重程度和症状持续时间有深远影响。
