Duan Zhenghao, Lu Jie
Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China.
Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Psychiatry. 2020 Sep 3;11:538683. doi: 10.3389/fpsyt.2020.538683. eCollection 2020.
Depression is one of the most common psychiatric disorders affecting public health. Studies over the past years suggest that the methylations of some specific genes such as , , and play an important role in the development of depression. Recently, epigenetic evidences suggest that the expression levels of DNA methyltransferases differ in several brain areas including the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens in depression patients and animal models, but the potential link between the expression levels of DNA methylatransferases and the methylations of specific genes needs further investigation to clarify the pathogenesis of depression.
抑郁症是影响公众健康的最常见精神疾病之一。过去几年的研究表明，某些特定基因如[此处原文基因名称缺失]、[此处原文基因名称缺失]和[此处原文基因名称缺失]的甲基化在抑郁症的发生发展中起重要作用。最近，表观遗传学证据表明，在抑郁症患者和动物模型中，包括前额叶皮质、海马体、杏仁核和伏隔核在内的几个脑区中，DNA甲基转移酶的表达水平存在差异，但DNA甲基转移酶的表达水平与特定基因甲基化之间的潜在联系需要进一步研究，以阐明抑郁症的发病机制。
